B Cells Loaded with Synthetic Particulate Antigens: A Versatile Platform To Generate Antigen-Specific Helper T Cells for Cell Therapy

被引：12

作者：

Sicard, Antoine ^{[1
,2
,3
,4
]}

Koenig, Alice ^{[1
,2
,3
,4
]}

Graff-Dubois, Stephanie ^{[5
]}

Dussurgey, Sebastien ^{[6
]}

Rouers, Angeline ^{[5
]}

Dubois, Valerie ^{[7
]}

Blanc, Pascal ^{[1
,2
,3
]}

Chartoire, Dimitri ^{[1
,2
,3
]}

Errazuriz-Cerda, Elisabeth ^{[8
]}

Paidassi, Helena ^{[1
,2
,3
]}

Taillardet, Morgan ^{[1
,2
,3
]}

Morelon, Emmanuel ^{[1
,2
,3
,4
]}

Moris, Arnaud ^{[5
]}

Defrance, Thierry ^{[1
,2
,3
]}

Thaunat, Olivier ^{[1
,2
,3
,4
]}

机构：

[1] Int Ctr Infectiol Res CIRI, F-69007 Lyon, France

[2] Univ Lyon 1, INSERM Unit 1111, F-69007 Lyon, France

[3] Ecole Normale Super Lyon, CNRS, UMR 5308, F-69007 Lyon, France

[4] Hop Edouard Herriot, Transplantat Nephrol & Clin Immunol Dept, F-69003 Lyon, France

[5] Sorbonne Univ, Univ Paris 06, INSERM U1135, CNRS ERL 8255,Ctr Immunol & Microbial Infect CIMI, F-75013 Paris, France

[6] Univ Lyon 1, Ecole Normale Super, CNRS, INSERM,UMS344 US8,SFR Biosci, F-69007 Lyon, France

[7] French Natl Blood Serv EFS, F-69007 Lyon, France

[8] Univ Lyon 1, SFR Sante Lyon Est, Ctr Quantitat Imaging CIQLE, F-69372 Lyon, France

来源：

NANO LETTERS | 2016年 / 16卷 / 01期

关键词：

bioengineered nanoparticle; biomimetic; B cell; antigen-presenting cell; CD4+T cell; cell therapy; METASTATIC MELANOMA; PRESENTING CELLS; REGULATORY CELLS; DENDRITIC CELLS; EARLY EVENTS; CD4+T CELLS; FH CELLS; IN-VITRO; ACTIVATION; LYMPHOCYTES;

D O I：

10.1021/acs.nanolett.5b03801

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Adoptive cell therapy represents a promising approach for several chronic diseases. This study describes an innovative strategy for biofunctionalization of nanoparticles, allowing the generation of synthetic particulate antigens (SPAg). SPAg activate polyclonal B cells and vectorize noncognate proteins into their endosomes, generating highly efficient stimulators for ex vivo expansion of antigen-specific CD4+ T cells. This method also allows harnessing the ability of B cells to polarize CD4+ T cells into effectors or regulators.

引用

页码：297 / 308

页数：12

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