Outcomes and toxicities of re-irradiation for prostate cancer: A systematic review on behalf of the Re-Irradiation Working Group of the Italian Association of Radiotherapy and Clinical Oncology (AIRO)

被引：22

作者：

Munoz, Fernando ^{[1
]}

Fiorica, Francesco ^{[2
]}

Caravatta, Luciana ^{[3
]}

Rosa, Consuelo ^{[3
]}

Ferella, Letizia ^{[1
]}

Boldrini, Luca ^{[4
]}

Fionda, Bruno ^{[4
]}

Alitto, Anna Rita ^{[4
]}

Nardangeli, Alessia ^{[4
]}

Dionisi, Francesco ^{[5
]}

Arcangeli, Stefano ^{[6
,7
]}

Di Marzo, Alessandro ^{[8
]}

Pontoriero, Antonio ^{[9
]}

Donato, Vittorio ^{[10
]}

Massaccesi, Mariangela ^{[4
]}

机构：

[1] Parini Hosp, Radiotherapy Unit, Viale Ginevra 3, I-11100 Aosta, Italy

[2] State Hosp Mater Salutis AULSS 9, Dept Radiat Oncol & Nucl Med, Via Carlo Gianella 1, I-37045 Legnago, VR, Italy

[3] Univ G dAnnunzio, SS Annunziata Hosp, Radiat Oncol Unit, Via Vestini, I-66100 Chieti, Italy

[4] Univ Cattolica Sacro Cuore, Fdn Policlin Univ A Gemelli, Dept Radiol Radiotherapy & Hematol Sci, Via Pineta Sacchetti 217, I-00168 Rome, Italy

[5] APSS, Proton Therapy Unit, Dept Oncol, Via Alcide Degasperi 79, I-38123 Trento, Italy

[6] Policlin S Gerardo, Dept Radiat Oncol, Via Sansovino 4, I-20133 Milan, Italy

[7] Univ Milano Bicocca, Via Sansovino 4, I-20133 Milan, Italy

[8] S Maria Hosp, Radiotherapy Oncol Ctr, Viale Tristano Joannuccio, I-05100 Terni, Italy

[9] Univ Hosp G Martino, Dept Image Diagnost, Operat Unit Radiat Oncol, Messina, Italy

[10] Azienda Osped San Camillo Forlanini, Radiat Oncol, Circonvallaz Gianicolense 87, I-00152 Rome, Italy

来源：

CANCER TREATMENT REVIEWS | 2021年 / 95卷

关键词：

Cumulative dose; Outcomes; Prostate cancer; Re-irradiation; Toxicity; DOSE-RATE BRACHYTHERAPY; BEAM RADIATION-THERAPY; SALVAGE BRACHYTHERAPY; RECURRENCE; FAILURE;

D O I：

10.1016/j.ctrv.2021.102176

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aims: The best therapeutic approach for local relapses of previously irradiated prostate cancer (PC) is still not defined. Re-irradiation (Re-I) could offer a chance of cure for highly selected patients, although high quality evidences are lacking. The aim of our study is to provide a literature review on efficacy and safety of Re-I. Methods: Only studies where Re-I field overlaps with previous radiotherapy were considered. To determine 2 and 4 years overall mortality (OM), 2 and 4 years biochemical failure (BF) and pooled acute and late G 0.001). The pooled result of G 0.001). One hundred and three G 3 late adverse events were reported, with a pooled result of G > 3 late toxicity of 8.7% (95%CI: 5.8?13%, P < 0.001). Conclusions: Re-I of local failures from PC showed promising OM and biochemical control rates with a safe toxicity profile.

引用

页数：10

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