Lipid droplets in leukocytes: Organelles linked to inflammatory responses

被引：54
|
作者：
Melo, Rossana C. N. [1 ,2 ]
Weller, Peter F. [2 ]
机构：
[1] Univ Fed Juiz de Fora, Dept Biol, Lab Cellular Biol, ICB,UFJF, Rua Jose Lourenco Kelmer, BR-36036900 Juiz De Fora, MG, Brazil
[2] Harvard Univ, Sch Med, Dept Med, Beth Israel Deaconess Med Ctr, 330 Brookline Ave,CLS 943, Boston, MA 02215 USA
来源：
EXPERIMENTAL CELL RESEARCH | 2016年 / 340卷 / 02期
基金：
美国国家卫生研究院;
关键词：
Lipid bodies; Inflammation; Eicosanoids; Immune responses; Cell activation; Electron microscopy; ULTRASTRUCTURAL IMMUNOGOLD LOCALIZATION; ENDOPEROXIDE SYNTHASE CYCLOOXYGENASE; HUMAN EOSINOPHILS; ARACHIDONIC-ACID; EICOSANOID SYNTHESIS; BODIES; CELLS; MACROPHAGES; GENERATION; SITES;
D O I：
10.1016/j.yexcr.2015.10.028
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Studies on lipid droplets (LDs) in leukocytes have attracted attention due to their association with human diseases. In these cells, LDs are rapidly formed in response to inflammatory stimuli or allergic/inflammatory diseases including infections with parasites and bacteria. Leukocyte LDs are linked to the regulation of immune responses by compartmentalization of several proteins and lipids involved in the control and biosynthesis of inflammatory mediators (eicosanoids). In this mini review, we summarize current knowledge on the composition, structure and function of leukocyte LDs, organelles now considered as structural markers of inflammation. (C) 2015 Elsevier Inc. All rights reserved.
引用
收藏
页码：193 / 197
页数：5
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