Practical High-Throughput Experimentation for Chemists

被引：245

作者：

Shevlin, Michael ^{[1
]}

机构：

[1] Merck & Co Inc, Dept Proc Res & Dev, 126 East Lincoln Ave, Rahway, NJ 07065 USA

来源：

ACS MEDICINAL CHEMISTRY LETTERS | 2017年 / 8卷 / 06期

关键词：

High-throughput experimentation; ASYMMETRIC ALKENE HYDROGENATION; REACTION DISCOVERY; DRUG DISCOVERY; BOND FORMATION; CHROMATOGRAPHY; CATALYSTS; ENANTIOPURITY; INHIBITORS; GENERATE;

D O I：

10.1021/acsmedchemlett.7b00165

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Large arrays of hypothesis-driven, rationally designed experiments are powerful tools for solving complex chemical problems. Conceptual and practical aspects of chemical high-throughput experimentation are discussed. A case study in the application of high-throughput experimentation to a key synthetic step in a drug discovery program and subsequent optimization for the first large scale synthesis of a drug candidate is exemplified.

引用

页码：601 / 607

页数：7

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