Sarcolipin Makes Heat, but Is It Adaptive Thermogenesis?

被引：31
|
作者：
Campbell, Kevin L. [1 ]
Dicke, Alysha A. [2 ]
机构：
[1] Univ Manitoba, Dept Biol Sci, Winnipeg, MB, Canada
[2] Fish & Richardson PC, Minneapolis, MN USA
来源：
FRONTIERS IN PHYSIOLOGY | 2018年 / 9卷
基金：
加拿大自然科学与工程研究理事会;
关键词：
sarcolipin; thermogenesis; evolution; muscle; calcium; SERCA; SKELETAL-MUSCLE; RETICULUM CA2+-ATPASE; COLD ADAPTATION; ATPASE SERCA; N-TERMINUS; CA2+; PHOSPHOLAMBAN; EXPRESSION; PROTEIN; OVEREXPRESSION;
D O I：
10.3389/fphys.2018.00714
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
A regulatory protein (sarcolipin or SLN) bound to SERCA pumps in the sarcoplasmic reticulum (SR) of cardiac and skeletal muscle has been shown to increase heat production in vitro. Here, we review recent work in this area, assess the potential of in vivo heat generation by this mechanism, and advocate that a comparative approach is the best path toward resolving many outstanding questions on the physiological function, regulation, and evolution of SLN.
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页数：7
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