Effects of galectin-1 on immunomodulatory properties of human monocyte-derived dendritic cells

被引：7
|
作者：
Dzopalic, Tanja [1 ]
Kostic, Milos [1 ]
Kostic, Milena [2 ]
Marjanovic, Goran [1 ,3 ]
Guzina, Jelena [2 ]
Jurisic, Vladimir [4 ]
Nedeljkovic, Biljana Bozic [2 ]
机构：
[1] Univ Nis, Med Fac, Dept Immunol, Nish, Serbia
[2] Univ Belgrade, Fac Biol, Inst Physiol & Biochem Ivan Djaja, Belgrade, Serbia
[3] Clin Ctr Nis, Clin Hematol & Clin Immunol, Nish, Serbia
[4] Univ Kragujevac, Fac Med Sci, Svetozara Markovica 69, Kragujevac 34000, Serbia
来源：
GROWTH FACTORS | 2020年 / 38卷 / 5-6期
关键词：
Galectin-1; immunomodulation; monocyte-derived dendritic cells; T-CELLS; IMMUNE-RESPONSES; ACTIVATION; BINDING; IL-10; INTERLEUKIN-2; CD83; LOCALIZATION; EXPRESSION; RECEPTORS;
D O I：
10.1080/08977194.2021.1947267
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Our study aimed to evaluate the effects of Gal-1 in dose depending manner on maturation and immunomodulatory properties of monocyte-derived (Mo) DCs in-vitro. The effects were analyzed by monitoring their phenotypic characteristics, cytokine profile, and the ability to direct the immune response in the co-culture with allogeneic CD4(+)T cells. Gal-1 reduced the expression of CD80 and CD86 molecules on MoDCs compared to untreated MoDCs. Gal-1 at concentrations of 1 and 6 mu g/mL significantly reduced IL-12 production, while the concentration of 3 mu g/mL led to its significant increase. Gal-1 in all concentrations induced a significant increase in the production of IL-10. Treatment of MoDCs with 3 and 6 mu g/mL of Gal-1 stimulated the production of IL-2 and IFN-gamma in the co-culture with CD4(+)T lymphocytes. This study demonstrated a dual immunomodulatory effect of Gal-1 on MoDCs in terms of immune stimulation and immune suppression, depending on the applied concentration.
引用
收藏
页码：235 / 246
页数：12
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