Multifactorial Prevention of Cardiovascular Disease in Patients with Hypertension: the Cardiovascular Polypill

被引：19
作者：
Lafeber, M. [1 ,2 ]
Spiering, W. [2 ]
Visseren, F. L. J. [2 ]
Grobbee, D. E. [1 ]
机构：
[1] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands
[2] Univ Med Ctr Utrecht, Dept Vasc Med, Utrecht, Netherlands
来源：
CURRENT HYPERTENSION REPORTS | 2016年 / 18卷 / 05期
关键词：
Polypill; Fixed-dose combination therapy; Combination pill; Adherence; Hypertension; Cholesterol; Prevention; DOSE COMBINATION TREATMENT; BLOOD-PRESSURE; HIGH-RISK; PRACTICE GUIDELINES; CLINICAL-PRACTICE; CONTROLLED-TRIAL; THERAPY; HEALTH; METAANALYSIS; CHOLESTEROL;
D O I：
10.1007/s11906-016-0648-3
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
Hypertension is a major, if not the most important, contributor to the disease burden and premature death globally which is largely related to cardiovascular disease. In both the primary and the secondary preventions of cardiovascular disease, blood pressure (BP) targets are often not achieved which is similar to achievement of cholesterol goals. Combining aspirin, cholesterol and blood pressure-lowering agents into a fixed-dose combination pill called the cardiovascular polypill has been proposed as complementary care in the prevention of cardiovascular diseases in both the primary and secondary preventions of cardiovascular disease. This review article focuses on the potential role of fixed-dose combination therapy in the treatment of hypertension, outlines the pros and cons of combination therapy and emphasizes the rationale for trialling their use. Current and planned future cardiovascular polypill trials are summarized, and the prerequisites for implementation of the polypill strategy are described.
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页数：7
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