Effect of Reactive Oxygen Species on the Endoplasmic Reticulum and Mitochondria during Intracellular Pathogen Infection of Mammalian Cells

被引：62
作者：
Lee, Junghwan [1 ,2 ,3 ]
Song, Chang-Hwa [1 ,2 ,3 ]
机构：
[1] Chungnam Natl Univ, Coll Med, Dept Med Sci, 266 Munhwa ro,Jung gu, Daejeon 35015, South Korea
[2] Chungnam Natl Univ, Coll Med, Dept Microbiol, 266 Munhwa ro,Jung gu, Daejeon 35015, South Korea
[3] Chungnam Natl Univ, Coll Med, Translat Immunol Inst, 266 Munhwa Ro, Daejeon 35015, South Korea
来源：
ANTIOXIDANTS | 2021年 / 10卷 / 06期
基金：
新加坡国家研究基金会;
关键词：
bacteria; ROS; mitochondria; ER stress; oxidative stress; pathogen; infection; MONOCYTE CHEMOATTRACTANT PROTEIN-1; MANGANESE SUPEROXIDE-DISMUTASE; STRESS-MEDIATED APOPTOSIS; SMOOTH-MUSCLE-CELLS; NF-KAPPA-B; OXIDATIVE STRESS; NADPH OXIDASE; ELECTRON-TRANSPORT; ER-STRESS; IMMUNE-RESPONSES;
D O I：
10.3390/antiox10060872
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Oxidative stress, particularly reactive oxygen species (ROS), are important for innate immunity against pathogens. ROS directly attack pathogens, regulate and amplify immune signals, induce autophagy and activate inflammation. In addition, production of ROS by pathogens affects the endoplasmic reticulum (ER) and mitochondria, leading to cell death. However, it is unclear how ROS regulate host defense mechanisms. This review outlines the role of ROS during intracellular pathogen infection, mechanisms of ROS production and regulation of host defense mechanisms by ROS. Finally, the interaction between microbial pathogen-induced ROS and the ER and mitochondria is described.
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页数：21
相关论文
共 236 条
[1]   ACTIVATION OF THE NADPH OXIDASE INVOLVES THE SMALL GTP-BINDING PROTEIN P21RAC1 [J].
ABO, A ;
PICK, E ;
HALL, A ;
TOTTY, N ;
TEAHAN, CG ;
SEGAL, AW .
NATURE, 1991, 353 (6345) :668-670
[2]   Mitochondria-Derived Vesicles Deliver Antimicrobial Reactive Oxygen Species to Control Phagosome-Localized Staphylococcus aureus [J].
Abuaita, Basel H. ;
Schultz, Tracey L. ;
O'Riordan, Mary X. .
CELL HOST & MICROBE, 2018, 24 (05) :625-+
[3]   The Endoplasmic Reticulum Stress Sensor Inositol-Requiring Enzyme 1α Augments Bacterial Killing through Sustained Oxidant Production [J].
Abuaita, Basel H. ;
Burkholder, Kristin M. ;
Boles, Blaise R. ;
O'Riordan, Mary X. .
MBIO, 2015, 6 (04)
[4]   ROS-Triggered Phosphorylation of Complex II by Fgr Kinase Regulates Cellular Adaptation to Fuel Use [J].
Acin-Perez, Rebeca ;
Carrascoso, Isabel ;
Baixauli, Francesc ;
Roche-Molina, Marta ;
Latorre-Pellicer, Ana ;
Fernandez-Silva, Patricio ;
Mittelbrunn, Maria ;
Sanchez-Madrid, Francisco ;
Perez-Martos, Acisclo ;
Lowell, Clifford A. ;
Manfredi, Giovanni ;
Antonio Enriquez, Jose .
CELL METABOLISM, 2014, 19 (06) :1020-1033
[5]   Lipid (per) oxidation in mitochondria: an emerging target in the ageing process? [J].
Ademowo, O. S. ;
Dias, H. K. I. ;
Burton, D. G. A. ;
Griffiths, H. R. .
BIOGERONTOLOGY, 2017, 18 (06) :859-879
[6]   Role of free radicals in viral pathogenesis and mutation [J].
Akaike, T .
REVIEWS IN MEDICAL VIROLOGY, 2001, 11 (02) :87-101
[7]   Pathogen recognition and innate immunity [J].
Akira, S ;
Uematsu, S ;
Takeuchi, O .
CELL, 2006, 124 (04) :783-801
[8]   Toll-like receptors: critical proteins linking innate and acquired immunity [J].
Akira, S ;
Takeda, K ;
Kaisho, T .
NATURE IMMUNOLOGY, 2001, 2 (08) :675-680
[9]   The cellular stress response in hepatitis C virus infection: A balancing act to promote viral persistence and host cell survival [J].
Alfredo Rios-Ocampo, W. ;
Navas, Maria-Cristina ;
Faber, Klaas Nico ;
Daemen, Toos ;
Moshage, Han .
VIRUS RESEARCH, 2019, 263 :1-8
[10]   Endoplasmic reticulum stress signalling - from basic mechanisms to clinical applications [J].
Almanza, Aitor ;
Carlesso, Antonio ;
Chintha, Chetan ;
Creedican, Stuart ;
Doultsinos, Dimitrios ;
Leuzzi, Brian ;
Luis, Andreia ;
McCarthy, Nicole ;
Montibeller, Luigi ;
More, Sanket ;
Papaioannou, Alexandra ;
Pueschel, Franziska ;
Sassano, Maria Livia ;
Skoko, Josip ;
Agostinis, Patrizia ;
de Belleroche, Jackie ;
Eriksson, Leif A. ;
Fulda, Simone ;
Gorman, Adrienne M. ;
Healy, Sandra ;
Kozlov, Andrey ;
Munoz-Pinedo, Cristina ;
Rehm, Markus ;
Chevet, Eric ;
Samali, Afshin .
FEBS JOURNAL, 2019, 286 (02) :241-278
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