Pd-Catalyzed Dehydrogenative Aryl-Aryl Bond Formation via Double C(sp2)-H Bond Activation:, Efficient Synthesis of [3,4]-Fused Oxindoles

被引：61

作者：

Bunescu, Ala ^{[1
]}

Piou, Tiffany ^{[1
]}

Wang, Qian ^{[1
]}

Zhu, Jieping ^{[1
]}

机构：

[1] Ecole Polytech Fed Lausanne, Lab Synth & Nat Prod, Inst Chem Sci & Engn, EPFL SB ISIC LSPN, CH-1015 Lausanne, Switzerland

来源：

ORGANIC LETTERS | 2015年 / 17卷 / 02期

基金：

瑞士国家科学基金会;

关键词：

C-H ACTIVATION; INTRAMOLECULAR HECK REACTION; PALLADIUM MIGRATION; DOMINO REACTION; CYCLIZATION; SPIROOXINDOLES; CONSTRUCTION; CASCADE; REARRANGEMENT; POLYFLUORENES;

D O I：

10.1021/ol503442n

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A Pd(0)-catalyzed double cyclization of easily available o-bromoanilides leading to strained [3,4]-fused oxindoles was developed. The reaction proceeded through a highly ordered sequence involving key carbopalladation, 1,4-Pd migration, and C(sp(2))H functionalization steps.

引用

收藏

页码：334 / 337

页数：4

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