The epidemiology and etiology of differentiated thyroid carcinoma

被引：37

作者：

Busnardo, B ^{[1
]}

De Vido, D ^{[1
]}

机构：

[1] Ist Semeiot Med, Dipartiemnto Sci Med & Chirurg, I-35100 Padua, Italy

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2000年 / 54卷 / 06期

关键词：

differentiated thyroid carcinoma; papillary carcinoma; follicular carcinoma; prognosis; radiation exposure; child;

D O I：

10.1016/S0753-3322(00)80056-6

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Differentiated thyroid carcinoma (DTC) is a rare tumor with a relatively good prognosis, but in about 10% of cases it may be the cause of death. Papillary carcinoma is more frequent (about 70-80% of cases) and less aggressive than follicular cancer: the papillary/follicular ratio is increased in areas of high iodine intake. In recent years many genes have been found to be mutated in DTC, the most important of these bring ras, ret, trk, and met. The relationship between radiation exposure and DTC is well recognized, especially in children. Since the Chernobyl nuclear accident, a high incidence of DTC has been found in children exposed to fallout. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

引用

页码：322 / 326

页数：5

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