Intramucosal Helicobacter pylori in the human and murine stomach:: Its relationship to the inflammatory reaction in human Helicobacter pylori gastritis

被引:6
作者
Min, K
Hong, SM
Kim, KR
Ro, JY
Park, MJ
Kim, JS
Kim, JM
Jung, HC
Yu, E
机构
[1] Univ Ulsan, Dept Pathol, Coll Med, Asan Med Ctr, Seoul 138736, South Korea
[2] Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul 151, South Korea
[3] Hanyang Univ, Dept Microbiol, Coll Med, Seoul 133791, South Korea
[4] Hanyang Univ, Inst Biomed Sci, Coll Med, Seoul 133791, South Korea
关键词
Helicobacter pylori; gastric mucosa; gastritis; intramucosal; human; mice; neutrophil;
D O I
10.1078/0344-0338-00345
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Intramucosal Helicobacter pylori (H. pylori) has been described in biopsy tissues and culture systems. However, the association of intramucosal H. pylori with histopathologic features has not been evaluated. The purpose of this study is to investigate the relationship between intramucosal H. pylori and inflammatory reactions in H. pylori infection. In 113 randomly selected human gastric biopsies and 20 murine stomachs, which were inoculated with SS1 every day for a week, immunohistochemical analysis for intramucosal H. pylori was done and correlated with histologic parameters. Electron microscopic examination was done on murine stomachs. H. pylori infection was present in 104 gastric biopsies and 17 murine stomachs. Intraepithelial immunopositivity for H. pylori was detected in 27 of 104 (26%) biopsies and in 11 of 17 (65%) murine stomachs. Lamina proprial immunopositivity for H. pylori was present in 51 of 104 (48%) biopsies. Neutrophil-associated immunopositivity for H. pylori was observed in 22 of 90 (24%) biopsies with H. pylori chronic active gastritis. Lamina proprial and neutrophil-associated immunopositivity for H. pylori correlated significantly with the density of H. pylori and the grade of acute inflammatory reaction in H. pylori gastritis. Intramucosal location of H. pylori itself or its antigen is closely associated with acute inflammatory reactions and may play an important role in establishing a persistent infection in chronic H. pylori gastritis. Furthermore, lamina proprial and/or neutrophil-associated H. pylori appears to be more important than intraepithelial H. pylori in acute inflammatory reactions of H. pylori gastritis.
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页码:1 / 8
页数:8
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