The neuroinvasiveness, neurotropism, and neurovirulence of SARS-CoV-2

被引：137
作者：
Bauer, Lisa [1 ]
Laksono, Brigitta M. [1 ]
de Vrij, Femke M. S. [2 ]
Kushner, Steven A. [2 ]
Harschnitz, Oliver [3 ]
van Riel, Debby [1 ]
机构：
[1] Erasmus MC, Dept Virosci, Rotterdam, Netherlands
[2] Erasmus MC, Dept Psychiat, Rotterdam, Netherlands
[3] Human Technopole, Viale Rita Levi Montalcini 1, I-20157 Milan, Italy
来源：
TRENDS IN NEUROSCIENCES | 2022年 / 45卷 / 05期
关键词：
VIRUS-INFECTIONS; CHOROID-PLEXUS; COVID-19; CELLS; MODEL; IDENTIFICATION; BARRIER;
D O I：
10.1016/j.tins.2022.02.006
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) infection is as-sociated with a diverse spectrum of neurological complications during the acute and postacute stages. The pathogenesis of these complications is complex and dependent on many factors. For accurate and consistent interpretation of exper-imental data in this fast-growing field of research, it is essential to use terminol-ogy consistently. In this article, we outline the distinctions between neuroinvasiveness, neurotropism, and neurovirulence. Additionally, we discuss current knowledge of these distinct features underlying the pathogenesis of SARS-CoV-2-associated neurological complications. Lastly, we briefly discuss the advantages and limitations of different experimental models, and how these approaches can further be leveraged to advance the field.
引用
收藏
页码：358 / 368
页数：11
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