Impact of Smoking on the Survival of Patients With High-risk HPV-positive HNSCC: A Meta-analysis

被引：18

作者：

Alotaibi, Moonef ^{[1
,2
,3
,4
,5
]}

Valova, Valeria ^{[1
,2
,3
,4
]}

HAnsel, Toni ^{[1
,2
,3
,4
]}

Stromberger, Carmen ^{[1
,2
,3
,4
,6
]}

Kofla, Grzegorz ^{[1
,2
,3
,4
,7
]}

Olze, Heidi ^{[1
,2
,3
,4
]}

Piwonski, Iris ^{[1
,2
,3
,4
,8
]}

Albers, Andreas ^{[1
,2
,3
,4
,9
]}

Ochsenreither, Sebastian ^{[1
,2
,3
,4
,10
,11
]}

Coordes, Annekatrin ^{[1
,2
,3
,4
]}

机构：

[1] Charite Univ Med Berlin, Dept Otorhinolaryngol Head & Neck Surg CVK & CCM, Berlin, Germany

[2] Free Univ Berlin, Augustenburger Pl 1, D-13353 Berlin, Germany

[3] Humboldt Univ, Augustenburger Pl 1, D-13353 Berlin, Germany

[4] Berlin Inst Hlth, Berlin, Germany

[5] King Fahad Med City, Dept Otorhinolaryngol Head & Neck Surg, Riyadh, Saudi Arabia

[6] Charite Univ Med Berlin, Dept Radiooncol CVK, Berlin, Germany

[7] Charite Univ Med Berlin, Dept Oncol CVK, Berlin, Germany

[8] Charite Univ Med Berlin, Inst Pathol, Berlin, Germany

[9] Charite Univ Med Berlin, Dept Otorhinolaryngol CBF, Berlin, Germany

[10] Charite Univ Med Berlin, Dept Oncol CBF, Berlin, Germany

[11] Charite Comprehens Canc Ctr, Berlin, Germany

来源：

IN VIVO | 2021年 / 35卷 / 02期

关键词：

HNSCC; smoking; HPV; p16; PCR; ISH; SQUAMOUS-CELL CARCINOMA; HUMAN-PAPILLOMAVIRUS; OROPHARYNGEAL CANCER; NECK-CANCER; HEAD; STATISTICS; PROGNOSIS; OUTCOMES; P16;

D O I：

10.21873/invivo.12345

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Background/Aim: High risk Human papillomavirus (hr-HPV) and smoking are independant risk factors for head and neck squamous cell carcinomas (HNSCC). While hr-HPV+ HNSCC has a better prognosis than smoking-associated HNSCC no systematic data are yet available about the combined risk. Patients and Methods: We performed a meta-analysis to assess the overall survival of HNSCC patients relative to the hr-HPV+ and smoking status. A literature review up to November 2019 was conducted in PubMed and Cochrane Library using the search terms 'HPV, Smoking and HNSCC'. Results: Nine out of 748 articles were included, 1,436 out of 2,080 patients were hr-HPV+. The prevalence of hr-HPV - smokers was 36%. The meta-analysis showed a significantly better 5-year overall survival for HPV+ non-smokers compared to smokers with risk ratio of 1.94 (95% confidence interval=1.46-2.58). Conclusion: Smoking is a negative prognostic factor for overall survival in patients with hr-HPV+ HNSCC and should thus be an important part of staging and treatment.

引用

页码：1017 / 1026

页数：10

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