Hepatitis C: Current and future treatment

被引:0
作者
Keeffe, EB [1 ]
机构
[1] Stanford Univ, Med Ctr, Liver Transplant Program, Stanford, CA 94305 USA
关键词
hepatitis C; interferon; ribavirin; alfacon-1;
D O I
暂无
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Interferon alfa-2b, 3 million units tiw, plus ribavirin, 1000 to 1200 mg daily for 6 to 12 months, has shown an improvement of 2-fold or more for all measures of efficacy when compared with interferon monotherapy. Ln the next year, treatment of chronic hepatitis C will involve pegylated interferons, either alone or in combination with ribavirin. Therapy in 3 to 5 years will likely be multidrug combinations, including inhibitors of the hepatitis C virus (HCV) protease, helicase, or polymerase, with the aim of reducing serum levels or eradicating HCV RNA.
引用
收藏
页码:603 / +
页数:6
相关论文
共 36 条
[1]   Treatment strategies for chronic hepatitis C: Update since the 1997 National Institutes of Health Consensus Development Conference [J].
Ahmed, A ;
Keeffe, EB .
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 1999, 14 :S12-S18
[2]   The prevalence of hepatitis C virus infection in the United States, 1988 through 1994 [J].
Alter, MJ ;
Kruszon-Moran, D ;
Nainan, OV ;
McQuillan, GM ;
Gao, FX ;
Moyer, LA ;
Kaslow, RA ;
Margolis, HS .
NEW ENGLAND JOURNAL OF MEDICINE, 1999, 341 (08) :556-562
[3]  
[Anonymous], 1999, J Hepatol, V30, P956
[4]  
[Anonymous], 1997, HEPATOLOGY, V26, pS2
[5]  
[Anonymous], VIRAL HEPAT REV
[6]   Reduction of health-related quality of life in chronic hepatitis C and improvement with interferon therapy [J].
Bonkovsky, HL ;
Woolley, JM .
HEPATOLOGY, 1999, 29 (01) :264-270
[7]   Chronic hepatitis C:: Interferon retreatment of relapsers.: A meta-analysis of individual patient data [J].
Cammà, C ;
Giunta, M ;
Chemello, L ;
Alberti, A ;
Toyoda, H ;
Trepo, C ;
Marcellin, P ;
Zahm, F ;
Schalm, S ;
Craxi, A .
HEPATOLOGY, 1999, 30 (03) :801-807
[8]   Therapy of hepatitis C: Meta-analysis of interferon alfa-2b trials [J].
Carithers, RL ;
Emerson, SS .
HEPATOLOGY, 1997, 26 (03) :S83-S88
[9]   High-tech industry marketing: The elements of a sophisticated global strategy [J].
Davies, W ;
Brush, KE .
INDUSTRIAL MARKETING MANAGEMENT, 1997, 26 (01) :1-13
[10]  
Davis GL, 1999, SEMIN LIVER DIS, V19, P103