Can coronavirus disease 2019 (COVID-19) trigger exacerbation of multiple sclerosis? A retrospective study

被引：52
作者：
Barzegar, Mahdi [1 ,2 ]
Vaheb, Saeed [2 ,3 ]
Mirmosayyeb, Omid [1 ,2 ]
Afshari-Safavi, Alireza [2 ,4 ]
Nehzat, Nasim [2 ]
Shaygannejad, Vahid [1 ,2 ]
机构：
[1] Isfahan Univ Med Sci, Sch Med, Dept Neurol, Esfahan, Iran
[2] Isfahan Univ Med Sci, Isfahan Neurosci Res Ctr, Esfahan, Iran
[3] Isfahan Univ Med Sci, Fac Paramed, Student Res Comm, Esfahan, Iran
[4] North Khorasan Univ Med Sci, Fac Hlth, Dept Biostat & Epidemiol, Bojnurd, Iran
来源：
MULTIPLE SCLEROSIS AND RELATED DISORDERS | 2021年 / 52卷
关键词：
Multiple sclerosis; Coronavirus; Infection; Relapse; Exacerbation; INFECTIONS;
D O I：
10.1016/j.msard.2021.102947
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The effect of coronavirus disease (COVID-19) on the risk of relapse in multiple sclerosis (MS) have been unknown. In this retrospective study of 41 relapsing-remitting MS patients, number of relapses in pre-defined at risk-period (ARP) was compared with the previous two years. During the previous two years, a total of 32 attacks was reported, which 5 (15.6%) were during the at-risk period. After adjusting for age and sex, there was an increased risk of attack during ARP compared to the previous two years (RR: 2.566, 95%CI: 1.075-6.124, P=0.034). Our preliminary study suggested that COVID-19 can trigger exacerbation of MS.
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