The Neurobiological Bases of Memory Formation: From Physiological Conditions to Psychopathology

被引：47

作者：

Bisaz, Reto ^{[1
]}

Travaglia, Alessio ^{[1
]}

Alberini, Cristina M. ^{[1
]}

机构：

[1] NYU, Ctr Neural Sci, New York, NY 10003 USA

来源：

PSYCHOPATHOLOGY | 2014年 / 47卷 / 06期

关键词：

Memory; Stress; Molecular mechanisms; Consolidation; Reconsolidation; Retrieval; Posttraumatic stress disorder; LONG-TERM-MEMORY; EARLY ADVERSE EXPERIENCE; CONTEXTUAL FEAR MEMORY; GYRUS GRANULE NEURONS; ENDOCANNABINOID SYSTEM; PROTEIN-SYNTHESIS; NEUROTROPHIC FACTOR; MOLECULAR-BIOLOGY; SPATIAL MEMORY; RECONSOLIDATION;

D O I：

10.1159/000363702

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

The formation of long-term memories is a function necessary for an adaptive survival. In the last two decades, great progress has been made in the understanding of the biological bases of memory formation. The identification of mechanisms necessary for memory consolidation and re-consolidation, the processes by which the posttraining and postretrieval fragile memory traces become stronger and insensitive to disruption, has indicated new approaches for investigating and treating psychopathologies. In this review, we will discuss some key biological mechanisms found to be critical for memory consolidation and strengthening, the role/s and mechanisms of memory reconsolidation, and how the interference with consolidation and/or reconsolidation can modulate the retention and/or storage of memories that are linked to psychopathologies. (C) 2014 S. Karger AG, Basel

引用

页码：347 / 356

页数：10

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