Intracholecystic Papillary-tubular Neoplasm of the Gallbladder Presenting with Jaundice

被引：17

作者：

Hashimoto, Shinichi ^{[1
,2
]}

Horaguchi, Jun ^{[2
]}

Fujita, Naotaka ^{[2
]}

Noda, Yutaka ^{[2
]}

Kobayashi, Go ^{[2
]}

Ito, Kei ^{[2
]}

Koshida, Shinsuke ^{[2
]}

Kanno, Yoshihide ^{[2
]}

Ogawa, Takahisa ^{[2
]}

Masu, Kaori ^{[2
]}

机构：

[1] Kagoshima Univ, Grad Sch Med & Dent Sci, Hlth Res Course Human & Environm Sci, Dept Digest & Lifestyle Related Dis, Kagoshima 890, Japan

[2] Sendai City Med Ctr, Dept Gastroenterol, Sendai, Miyagi, Japan

来源：

INTERNAL MEDICINE | 2014年 / 53卷 / 20期

关键词：

intracholecystic papillary-tubular neoplasms; ICPN; gallbladder cancer; mucin-producing tumor; intraductal papillary neoplasm of the bile duct; IPNB; MUTATIONS; PANCREAS; DUCT;

D O I：

10.2169/internalmedicine.53.2778

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We herein report a case of intracholecystic papillary-tubular neoplasm (ICPN) of the gallbladder in which jaundice developed. A 58-year-old woman with jaundice was referred to our hospital. Computed tomography revealed a papillary tumor in the body of the gallbladder protruding into the bile duct. A transpapillary biopsy of the bile duct verified adenocarcinoma, and pancreatoduodenectomy with extended cholecystectomy was performed. The tumor spread macroscopically from the gallbladder body to the cystic duct, thus forming a polypoid mass protruding into the bile duct. This is a rare case of invasive carcinoma from ICPN leading to mechanical obstruction of the bile duct.

引用

页码：2313 / 2317

页数：5

共 8 条

[1] Intracholecystic Papillary-Tubular Neoplasms (ICPN) of the Gallbladder (Neoplastic Polyps, Adenomas, and Papillary Neoplasms That Are ≥ 1.0 cm) Clinicopathologic and Immunohistochemical Analysis of 123 Cases [J].

Adsay, Volkan ;

Jang, Kee-Taek ;

Carlos Roa, Juan ;

Dursun, Nevra ;

Ohike, Nobuyuki ;

Bagci, Pelin ;

Basturk, Olca ;

Bandyopadhyay, Sudeshna ;

Cheng, Jeanette D. ;

Sarmiento, Juan M. ;

Tapia Escalona, Oscar ;

Goodman, Michael ;

Kong, So Yeon ;

Terry, Paul .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2012, 36 (09) :1279-1301

[2] Whole-exome sequencing uncovers frequent GNAS mutations in intraductal papillary mucinous neoplasms of the pancreas [J].

Furukawa, Toru ;

Kuboki, Yuko ;

Tanji, Etsuko ;

Yoshida, Shoko ;

Hatori, Takashi ;

Yamamoto, Masakazu ;

Shibata, Noriyuki ;

Shimizu, Kyoko ;

Kamatani, Naoyuki ;

Shiratori, Keiko .

SCIENTIFIC REPORTS, 2011, 1

[3]

Japanese Society of Biliary Surgery, 2003, GEN RUL SURG PATH ST, P30

[4] GNAS codon 201 mutations are uncommon in intraductal papillary neoplasms of the bile duct [J].

Matthaei, Hanno ;

Wu, Jian ;

Dal Molin, Marco ;

Debeljak, Marija ;

Lingohr, Philipp ;

Katabi, Nora ;

Klimstra, David S. ;

Adsay, N. Volkan ;

Eshleman, James R. ;

Schulick, Richard D. ;

Kinzler, Kenneth W. ;

Vogelstein, Bert ;

Hruban, Ralph H. ;

Maitra, Anirban .

HPB, 2012, 14 (10) :677-683

[5]

Nemoto A, 2003, HEPATO-GASTROENTEROL, V50, P1250

[6] Mucin-producing carcinoma of the gallbladder associated with primary sclerosing cholangitis and ulcerative colitis [J].

Noda, Hiroshi ;

Chiba, Fumihiro ;

Toyama, Nobuyuki ;

Konishi, Fumio .

JOURNAL OF HEPATO-BILIARY-PANCREATIC SURGERY, 2009, 16 (01) :83-85

[7]

SOBIN LH, 2002, TNM CLASSIFICATION M, P84

[8] Biliary papillary tumors share pathological features with intraductal papillary mucinous neoplasm of the pancreas [J].

Zen, Yoh ;

Fujii, Takahiko ;

Itatsu, Keita ;

Nakamura, Koichi ;

Minato, Hiroshi ;

Kasashima, Satomi ;

Kurumaya, Hiroshi ;

Katayanagi, Kazuyoshi ;

Kawashima, Atsuhiro ;

Masuda, Shinji ;

Niwa, Hideki ;

Mitsui, Takeshi ;

Asada, Yasuyuki ;

Miura, Shouji ;

Ohta, Tetsuo ;

Nakanuma, Yasuni .

HEPATOLOGY, 2006, 44 (05) :1333-1343

← 1 →