Chemokine CXCL-1 Expression in the Subretinal Fluid during Rhegmatogenous Retinal Detachment

被引：5

作者：

Symeonidis, Chrysanthos ^{[1
]}

Androudi, Sofia ^{[2
]}

Rotsos, Tryfon ^{[3
]}

Moschos, Marilita M. ^{[3
]}

Souliou, Efimia ^{[4
]}

Dimitrakos, Stavros A. ^{[1
]}

Diza, Eudoxia ^{[5
]}

机构：

[1] Aristotle Univ Thessaloniki, Papageorgiou Gen Hosp, Sch Med, Dept Ophthalmol 2, Thessaloniki 56403, Macedonia, Greece

[2] Univ Thessaly, Univ Hosp, Dept Ophthalmol, Larisa, Thessaly, Greece

[3] Univ Athens, Sch Med, G Gennimatas Hosp, Dept Ophthalmol 1, GR-11527 Athens, Greece

[4] Aristotle Univ Thessaloniki, Sch Med, Dept Microbiol 1, Thessaloniki 56403, Macedonia, Greece

[5] Aristotle Univ Thessaloniki, AHEPA Univ Hosp, Dept Microbiol, Thessaloniki 56403, Macedonia, Greece

来源：

OCULAR IMMUNOLOGY AND INFLAMMATION | 2014年 / 22卷 / 06期

关键词：

CXCL-1; GRO-alpha; proliferative vitreoretinopathy; rhegmatogenous retinal detachment; subretinal fluid; SPINAL-CORD-INJURY; PROLIFERATIVE VITREORETINOPATHY; GRO-ALPHA; INTERLEUKIN-6; EXTENT; PVR;

D O I：

10.3109/09273948.2013.863942

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Purpose: To investigate the expression of chemokine CXCL-1 in the subretinal fluid (SRF) during rhegmatogenous retinal detachment (RRD) and identify potential correlations with number of quadrants involved and duration of the detachment. Methods and Results: Inclusion criteria were patients aged 18 years or older and primary RRD possibly complicated by proliferative vitreoretinopathy (PVR). CXCL-1 levels were measured in 36 SRF samples from 36 RRD patients. Mean CXCL-1 levels (102 +/- 37 pg/mL) were significantly higher (p = 0.050) compared to controls. CXCL-1 levels correlated significantly with age (p = 0.001) and RRD duration (p = 0.002). Maximum CXCL-1 levels coincided with total RRD, 29- to 60-day duration and PVR grade C. Conclusions: The findings of this study may contribute to increased understanding regarding the role of CXCL-1 during the onset and progression of the wound healing process in the context of RRD and PVR.

引用

页码：449 / 453

页数：5

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