Hepcidin, a new iron regulatory peptide

被引：269

作者：

Nicolas, G

Viatte, L

Bennoun, M

Beaumont, C

Kahn, A

Vaulont, S

机构：

[1] Fac Med Cochin, Dept Genet Dev & Pathol Mol, Inst Cochin, F-75014 Paris, France

[2] Inst Cochin, INSERM, Dept Genet Dev & Pathol Mol, CNRS, F-75014 Paris, France

[3] Univ Paris 05, Fac Med Cochin Port Royal, F-75014 Paris, France

[4] Univ Paris 07, INSERM, F-75018 Paris, France

来源：

BLOOD CELLS MOLECULES AND DISEASES | 2002年 / 29卷 / 03期

关键词：

D O I：

10.1006/bcmd.2002.0573

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Maintaining normal iron homeostasis is essential for the organism, as both iron deficiency and iron excess are associated with cellular dysfunction. Recently, several lines of evidence have suggested that hepcidin, a peptide mainly produced by the liver, plays a major role in the control of body iron homeostasis. The subject of this paper is to summarize the advances toward the understanding of function and regulation of hepcidin in iron metabolism and to provide new data on the regulation of hepcidin gene expression by erythropoietin, the major regulator of mammalian erythropoiesis. (C) 2002 Elsevier Science (USA).

引用

页码：327 / 335

页数：9

共 28 条

[1] Relationship between intestinal iron-transporter expression, hepatic hepcidin levels and the control of iron absorption [J].

Anderson, GJ ;

Frazer, DM ;

Wilkins, SJ ;

Becker, EM ;

Millard, KN ;

Murphy, TL ;

McKie, AT ;

Vulpe, CD .

BIOCHEMICAL SOCIETY TRANSACTIONS, 2002, 30 :724-726

[2] Iron homeostasis: Insights from genetics and animal models [J].

Andrews, NC .

NATURE REVIEWS GENETICS, 2000, 1 (03) :208-217

[3] Metal transporters and disease [J].

Andrews, NC .

CURRENT OPINION IN CHEMICAL BIOLOGY, 2002, 6 (02) :181-186

[4]

COURSELAUD B, 2002, J BIOL CHEM 0814, V14

[5] Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter [J].

Donovan, A ;

Brownlie, A ;

Zhou, Y ;

Shepard, J ;

Pratt, SJ ;

Moynihan, J ;

Paw, BH ;

Drejer, A ;

Barut, B ;

Zapata, A ;

Law, TC ;

Brugnara, C ;

Kingsley, PD ;

Palis, J ;

Fleming, MD ;

Andrews, NC ;

Zon, LI .

NATURE, 2000, 403 (6771) :776-781

[6] A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis [J].

Feder, JN ;

Gnirke, A ;

Thomas, W ;

Tsuchihashi, Z ;

Ruddy, DA ;

Basava, A ;

Dormishian, F ;

Domingo, R ;

Ellis, MC ;

Fullan, A ;

Hinton, LM ;

Jones, NL ;

Kimmel, BE ;

Kronmal, GS ;

Lauer, P ;

Lee, VK ;

Loeb, DB ;

Mapa, FA ;

McClelland, E ;

Meyer, NC ;

Mintier, GA ;

Moeller, N ;

Moore, T ;

Morikang, E ;

Prass, CE ;

Quintana, L ;

Starnes, SM ;

Schatzman, RC ;

Brunke, KJ ;

Drayna, DT ;

Risch, NJ ;

Bacon, BR ;

Wolff, RK .

NATURE GENETICS, 1996, 13 (04) :399-408

[7]

FINCH C, 1994, BLOOD, V84, P1697

[8]

Fleming MD, 1997, NAT GENET, V16, P383, DOI 10.1038/ng0897-383

[9] Mechanisms of iron accumulation in hereditary hemochromatosis [J].

Fleming, RE ;

Sly, WS .

ANNUAL REVIEW OF PHYSIOLOGY, 2002, 64 :663-680

[10] Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats [J].

Frazer, DM ;

Wilkins, SJ ;

Becker, EM ;

Vulpe, CD ;

McKie, AT ;

Trinder, D ;

Anderson, GJ .

GASTROENTEROLOGY, 2002, 123 (03) :835-844

← 1 2 3 →