The biomechanical integrin

被引:62
作者
Baker, Erin L. [2 ]
Zaman, Muhammad H. [1 ]
机构
[1] Boston Univ, Dept Biomed Engn, Boston, MA 02215 USA
[2] Univ Texas Austin, Dept Biomed Engn, Austin, TX 78712 USA
关键词
Integrin; Mechanotransduction; Cancer; Cell mechanics; Extracellular matrix; CELL-MATRIX ADHESION; EXTRACELLULAR-MATRIX; TRACTION FORCES; FOCAL ADHESIONS; MECHANICAL-STRESS; ALPHA-6-BETA-4; INTEGRIN; STRUCTURAL BASIS; SLOW DYNAMICS; MIGRATION; MODEL;
D O I
10.1016/j.jbiomech.2009.09.007
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
The integrin lies at the center of our efforts to understand mechanotransduction in the human body. Over the past two decades, a wealth of information has yielded important insights into integrin structure and functioning in biochemical pathways; however, relatively little emphasis has been placed on mechanics. In this article, we review the current knowledge base of integrin mechanobiology by examining the role of integrins in stabilizing tissue structure, the mechanisms of integrin force transfer, the process of cell migration, and the pathology of cancer. in order to successfully address the gaps in cancer and other disease research going forward, future efforts of integrin mechanobiology must focus on examining cells in 3D environments and integrating our current understanding into computational models that predict the behavior of integrins in non-equilibrium interactions. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码:38 / 44
页数:7
相关论文
共 129 条
[1]  
[Anonymous], 2004, Molecular Biology of the Cell
[2]  
[Anonymous], 297 WHO
[3]   Structure and mechanics of integrin-based cell adhesion [J].
Arnaout, M. Amin ;
Goodman, Simon L. ;
Xiong, Jian-Ping .
CURRENT OPINION IN CELL BIOLOGY, 2007, 19 (05) :495-507
[4]   Anchorage-dependent cell cycle progression [J].
Assoian, RK .
JOURNAL OF CELL BIOLOGY, 1997, 136 (01) :1-4
[5]   Extracellular Matrix Stiffness and Architecture Govern Intracellular Rheology in Cancer [J].
Baker, Erin L. ;
Bonnecaze, Roger T. ;
Zamao, Muhammad H. .
BIOPHYSICAL JOURNAL, 2009, 97 (04) :1013-1021
[6]   Force and focal adhesion assembly: a close relationship studied using elastic micropatterned substrates [J].
Balaban, NQ ;
Schwarz, US ;
Riveline, D ;
Goichberg, P ;
Tzur, G ;
Sabanay, I ;
Mahalu, D ;
Safran, S ;
Bershadsky, A ;
Addadi, L ;
Geiger, B .
NATURE CELL BIOLOGY, 2001, 3 (05) :466-472
[7]   Marching at the front and dragging behind:: differential α-Vβ3-integrin turnover regulates focal adhesion behavior [J].
Ballestrem, C ;
Hinz, B ;
Imhof, BA ;
Wehrle-Haller, B .
JOURNAL OF CELL BIOLOGY, 2001, 155 (07) :1319-1332
[8]   A model for shear stress-induced deformation of a flow sensor on the surface of vascular endothelial cells [J].
Barakat, AI .
JOURNAL OF THEORETICAL BIOLOGY, 2001, 210 (02) :221-236
[9]   Local measurements of viscoelastic parameters of adherent cell surfaces by magnetic bead microrheometry [J].
Bausch, AR ;
Ziemann, F ;
Boulbitch, AA ;
Jacobson, K ;
Sackmann, E .
BIOPHYSICAL JOURNAL, 1998, 75 (04) :2038-2049
[10]   CELL-ADHESION - COMPETITION BETWEEN NONSPECIFIC REPULSION AND SPECIFIC BONDING [J].
BELL, GI ;
DEMBO, M ;
BONGRAND, P .
BIOPHYSICAL JOURNAL, 1984, 45 (06) :1051-1064