The first stereoselective total synthesis of (6,S)-5,6-dihydro-1(2R)-2-hydroxy-6-phenylhexyl]-2H-pyran-2-one

被引：37
作者：
Chandrasekhar, S [1 ]
Narsihmulu, C [1 ]
Sultana, SS [1 ]
Reddy, MS [1 ]
机构：
[1] Indian Inst Chem Technol, Hyderabad 500007, Andhra Pradesh, India
来源：
TETRAHEDRON LETTERS | 2004年 / 45卷 / 50期
关键词：
maruoka asymmetric allylation; Keck asymmetric allylation; ring-closing metathesis;
D O I：
10.1016/j.tetlet.2004.10.059
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Iterative asymmetric allylations and ring-closing metathesis have been effectively performed for the first stereoselective total synthesis of (6S)-5,6-dihydro-6-[(2R)-2-liydroxy-6-phenylhexyl]-2H-pyran-2-one, a novel alpha,beta-unsaturated-delta-lactone having antifungal activity, isolated from Rauensara crassifolia. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：9299 / 9301
页数：3
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