Induction of tumor necrosis factor-α mRNA in the kidney of the mouse chronic hepatitis model

被引：1

作者：

Okamoto, T

Furuya, M

Yamakawa, T

Yamamura, K

Hino, O

机构：

[1] Japanese Fdn Canc Res, Inst Canc, Dept Expt Pathol, Toshima Ku, Tokyo 170, Japan

[2] Nippon Chemiphar Co Ltd, Res Labs, Misato, Saitama 341, Japan

[3] Kumamoto Univ, Sch Med, Inst Mol Embryol & Genet, Kumamoto 862, Japan

来源：

JAPANESE JOURNAL OF PHARMACOLOGY | 1998年 / 76卷 / 01期

关键词：

transgenic mouse; interferon; tumor necrosis factor;

D O I：

10.1254/jjp.76.97

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Previously we reported the induction of tumor necrosis factor (TNF)-alpha mRNA in the liver of interferon (IFN)-gamma transgenic mouse, which might be the result of IFN-gamma gene expression. In the present study, IFN-gamma mRNA was induced in the liver, kidney and lung. TNF-alpha mRNA was, however, induced in the liver and kidney, but not in the lung. Induction of interleukin (IL)-2 and IL-1 beta mRNA was lacking in any of these organs. The present result showed the induction of TNF-alpha mRNA expression in the kidney of transgenic mouse.

引用

页码：97 / 99

页数：3

共 9 条

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