No association between cSHMT genotypes and the risk of breast cancer in the Nurses' Health Study

被引：17
作者：
Bentley, A. R. [1 ]
Raiszadeh, F. [1 ]
Stover, P. J. [1 ]
Hunter, D. J. [2 ,3 ,4 ,5 ]
Hankinson, S. E. [2 ,3 ,4 ]
Cassano, P. A. [1 ]
机构：
[1] Cornell Univ, Div Nutr Sci, Ithaca, NY 14853 USA
[2] Harvard Univ, Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA 02115 USA
[3] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA
[4] Harvard Univ, Sch Med, Boston, MA 02115 USA
[5] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA
来源：
EUROPEAN JOURNAL OF CLINICAL NUTRITION | 2010年 / 64卷 / 01期
关键词：
breast cancer; cSHMT; MTHFR; folate; CYTOPLASMIC SERINE HYDROXYMETHYLTRANSFERASE; ONE-CARBON METABOLISM; MTHFR POLYMORPHISMS; FOLATE; HOMOCYSTEINE; DISEASE; GENES;
D O I：
10.1038/ejcn.2009.104
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
Objectives: Increased breast cancer risk has been observed with both low folate status and a functional polymorphism in methylenetetrahydrofolate reductase (MTHFR 677C -> T). Cytoplasmic serine hydroxymethyltransferase (cSHMT) affects the flow of one-carbon units through the folate metabolic network, but there is little research on a role for genetic variation in cSHMT in determining breast cancer risk. Methods: A nested case-control study within the Nurses' Health Study was used to investigate an association between cSHMT (1420C -> T) and breast cancer risk. Results: No evidence for an association between the cSHMT genotype and breast cancer was observed. There was also no evidence of a gene-gene interaction between cSHMT and MTHFR. Conclusions: There was no evidence of an association between the cSHMT genotype and breast cancer occurrence. Further research in populations with differing average folate intake may be required to fully understand the interactions of folate nutrition, sequence variation in folate genes and breast cancer risk. European Journal of Clinical Nutrition (2010) 64, 108-110; doi:10.1038/ejcn.2009.104; published online 26 August 2009
引用
收藏
页码：108 / 110
页数：3
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