Metabolomic studies of Pseudomonas aeruginosa

被引:103
作者
Mielko, Karolina Anna [1 ]
Jablonski, Slawomir Jan [2 ]
Milczewska, Justyna [3 ]
Sands, Dorota [3 ]
Lukaszewicz, Marcin [2 ]
Mlynarz, Piotr [1 ]
机构
[1] Wroclaw Univ Sci & Technol, Fac Chem, Bioorgan Chem Grp, Norwida 4-6, PL-50373 Wroclaw, Poland
[2] Univ Wroclaw, Biotransformat Dept, Plac Uniwersytecki 1, PL-50137 Wroclaw, Poland
[3] Mother & Child Inst, Kasprzaka 17a, PL-01211 Warsaw, Poland
关键词
Metabolomics; Metabolomic experiment; Cystic fibrosis; Pseudomonas aeruginosa; Strain identification; CYSTIC-FIBROSIS PATIENTS; NMR-SPECTROSCOPY; DATABASE; IDENTIFICATION; GENOMES; GROWTH;
D O I
10.1007/s11274-019-2739-1
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Pseudomonas aeruginosa is a common, Gram-negative environmental organism. It can be a significant pathogenic factor of severe infections in humans, especially in cystic fibrosis patients. Due to its natural resistance to antibiotics and the ability to form biofilms, infection with this pathogen can cause severe therapeutic problems. In recent years, metabolomic studies of P. aeruginosa have been performed. Therefore, in this review, we discussed recent achievements in the use of metabolomics methods in bacterial identification, differentiation, the interconnection between genome and metabolome, the influence of external factors on the bacterial metabolome and identification of new metabolites produced by P. aeruginosa. All of these studies may provide valuable information about metabolic pathways leading to an understanding of the adaptations of bacterial strains to a host environment, which can lead to new drug development and/or elaboration of new treatment and diagnostics strategies for Pseudomonas. [GRAPHICS] .
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页数:11
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