Practical synthesis of 1-aryl-6-(hydroxymethyl)-2-ketopiperazines via a 6-exo amide-epoxide cyclization

被引：17

作者：

Powell, NA ^{[1
]}

Ciske, FL ^{[1
]}

Clay, EC ^{[1
]}

Cody, WL ^{[1
]}

Downing, DM ^{[1
]}

Blazecka, PG ^{[1
]}

Holsworth, DD ^{[1
]}

Edmunds, JJ ^{[1
]}

机构：

[1] Pfizer Global Res & Dev, Michigan Labs, Ann Arbor, MI 48105 USA

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 22期

关键词：

D O I：

10.1021/ol048235t

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chiral 1-aryl-6-(hydroxymethyl)-2-ketopiperazines can be prepared via an operationally simple, 6-exo epoxide ring-opening cyclization to form the ketopiperazine C6-N1 bond in high yields and with excellent enantiomeric purity.

引用

页码：4069 / 4072

页数：4

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