Characterization of a novel orthoreovirus isolated from fruit bat, China

被引：37

作者：

Hu, Tingsong ^{[1
]}

Qiu, Wei ^{[1
]}

He, Biao ^{[2
]}

Zhang, Yan ^{[3
]}

Yu, Jing ^{[1
]}

Liang, Xiu ^{[1
]}

Zhang, Wendong ^{[4
]}

Chen, Gang ^{[1
]}

Zhang, Yingguo ^{[4
]}

Wang, Yiyin ^{[1
]}

Zheng, Ying ^{[1
]}

Feng, Ziliang ^{[1
]}

Hu, Yonghe ^{[5
]}

Zhou, Weiguo ^{[1
]}

Tu, Changchun ^{[2
]}

Fan, Quanshui ^{[1
]}

Zhang, Fuqiang ^{[1
]}

机构：

[1] Chengdu Mil Reg, Ctr Dis Control & Prevent, Chengdu, Peoples R China

[2] Acad Mil Med Sci, Inst Mil Vet, Changchun 130062, Peoples R China

[3] Fudan Univ, Shanghai Med Coll, Dept Biochem & Mol Biol, Shanghai 200030, Peoples R China

[4] Anim Epidem Dis Control Ctr, Kunming 650032, Yunnan Province, Peoples R China

[5] Chengdu Mil Reg PLA, Gen Hosp, Chengdu 610083, Peoples R China

来源：

BMC MICROBIOLOGY | 2014年 / 14卷

基金：

中国国家自然科学基金;

关键词：

Bat Orthoreovirus; Prevalence; Viral genome reassortment; CLASS GENOME SEGMENTS; AVIAN REOVIRUS; VIRUS; IDENTIFICATION; SEQUENCE; REASSORTMENT; CORONAVIRUS;

D O I：

10.1186/s12866-014-0293-4

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Background: In recent years novel human respiratory disease agents have been described for Southeast Asia and Australia. The causative pathogens were classified as pteropine orthoreoviruses with a strong phylogenetic relationship to orthoreoviruses of bat origin. Results: In this report, we isolated a novel Melaka-like reovirus (named "Cangyuan virus") from intestinal content samples of one fruit bat residing in China's Yunnan province. Phylogenetic analysis of the whole Cangyuan virus genome sequences of segments L, M and S demonstrated the genetic diversity of the Cangyuan virus. In contrast to the L and M segments, the phylogenetic trees for the S segments of Cangyuan virus demonstrated a greater degree of heterogeneity. Conclusions: Phylogenetic analysis indicated that the Cangyuan virus was a novel orthoreovirus and substantially different from currently known members of Pteropine orthoreovirus (PRV) species group.

引用

页数：8

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