Synthesis and Evaluation of Bis-pyrazoline Derivatives as Potential Antimicrobial Agents

被引：0
|
作者：
Altintop, Mehlika Dilek [1 ]
Abu Mohsen, Usama [2 ]
Karaca, Hulya [3 ]
Canturk, Zerrin [3 ]
Ozdemir, Ahmet [1 ]
机构：
[1] Anadolu Univ, Fac Pharm, Dept Pharmaceut Chem, TR-26470 Eskisehir, Turkey
[2] Al Azhar Univ, Fac Pharm, Dept Pharmaceut Chem, Gaza, Israel
[3] Anadolu Univ, Fac Pharm, Dept Pharmaceut Microbiol, TR-26470 Eskisehir, Turkey
来源：
LETTERS IN DRUG DESIGN & DISCOVERY | 2014年 / 11卷 / 10期
关键词：
Antimicrobial activity; pyrazole; thiazole; BIOLOGICAL EVALUATION; RESISTANCE;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
In the present study, 5,5'-(1,4-phenylene)bis[3-(2-thienyl)-4,5-dihydro-1H-pyrazole-1-(4-arylthiazol-2-yl)] derivatives (3a-h) were obtained via the reaction of 5,5'-(1,4-phenylene)bis[3-(2-thienyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide] (2) with phenacyl bromides. The synthesized compounds were investigated for their antimicrobial activity against various bacteria and Candida species. Among these derivatives, 5,5'-(1,4-phenylene)bis[3-(2-thienyl)-4,5-dihydro-1H-pyrazole-1-(4-(4-chlorophenyl)thiazol-2-yl)] (3b) and 5,5'-(1,4-phenylene)bis[3-(2-thienyl)-4,5-dihydro-1H-pyrazole- 1-(4-(4-methoxyphenyl) thiazol-2-yl)] (3d) showed notable antimicrobial activity.
引用
收藏
页码：1199 / 1203
页数：5
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