Higher platelet distribution width predicts poor prognosis in laryngeal cancer

被引：47

作者：

Zhang, Huan ^{[1
]}

Liu, Li ^{[2
]}

Fu, Shuang ^{[1
]}

Liu, Yan-Song ^{[3
]}

Wang, Changsong ^{[3
]}

Liu, Tiemin ^{[1
,4
]}

Liu, Zhi-Ping ^{[5
,6
]}

Wang, Rui-Tao ^{[1
,7
]}

Yu, Kai-Jiang ^{[3
,7
]}

机构：

[1] Harbin Med Univ, Harbin Med Univ Canc Hosp, Dept Internal Med, Harbin 150081, Heilongjiang, Peoples R China

[2] Harbin Med Univ, Dept Histol & Embryol, Harbin 150081, Heilongjiang, Peoples R China

[3] Harbin Med Univ, Harbin Med Univ Canc Hosp, Dept Intens Care Unit, Harbin 150081, Heilongjiang, Peoples R China

[4] Univ Texas Southwestern Med Ctr Dallas, Div Hypothalam Res, Dept Internal Med, Dallas, TX 75390 USA

[5] Univ Texas Southwestern Med Ctr Dallas, Dept Internal Med, Dallas, TX 75390 USA

[6] Univ Texas Southwestern Med Ctr Dallas, Dept Mol Biol, Dallas, TX 75390 USA

[7] Heilongjiang Acad Med Sci, Harbin 150081, Heilongjiang, Peoples R China

来源：

ONCOTARGET | 2017年 / 8卷 / 29期

关键词：

laryngeal cancer; platelet distribution width; prognosis; survival; EPITHELIAL OVARIAN-CANCER; VOLUME; PROGRESSION; THROMBOSIS; RATIO;

D O I：

10.18632/oncotarget.18306

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Activated platelets promote cancer progression and metastasis. However, the prognostic value of platelet indices in laryngeal cancer remains poorly understood. The purpose of this study was to investigate the predictive significance of platelet indices in laryngeal cancer. Results: Of the 241 patients, high platelet distribution width (PDW) levels were observed in 116 (48.1 %) patients. In the Kaplan-Meier analysis, increased PDW was significantly associated with a poorer overall survival (p < 0.001). In the multivariate Cox model, PDW was an independent prognostic index for overall survival (HR=4.381, 95% CI=2.313-8.298, P < 0.001). Method: The retrospective study included 241 consecutive patients with laryngeal cancer between January 2009 and December 2009. The relationships between PDW and clinicopathological characteristics were analyzed. Kaplan-Meier method and Cox regression were used to evaluate the prognostic impact of PDW. Conclusions: Elevated PDW might be a novel prognostic marker in laryngeal cancer.

引用

页码：48138 / 48144

页数：7

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