The biology of metastasis to a sanctuary site

被引：114
作者：
Palmieri, Diane
Chambers, Ann F.
Felding-Habermann, Brunhilde
Huang, Suyun
Steeg, Patricia S.
机构：
[1] NCI, Mol Therapeut Program, Ctr Canc Res, Lab Mol Pharmacol,Womens Canc Sect, Bethesda, MD 20892 USA
[2] Univ Western Ontario, Dept Oncol, London, ON, Canada
[3] Univ Western Ontario, Dept Pathol, London, ON, Canada
[4] Univ Western Ontario, Dept Med Biophys, London, ON, Canada
[5] London Reg Canc Program, London, ON, Canada
[6] Scripps Res Inst, Dept Mol & Expt Med, La Jolla, CA USA
[7] Univ Texas, MD Anderson Canc Ctr, Dept Neurosurg, Houston, TX 77030 USA
来源：
CLINICAL CANCER RESEARCH | 2007年 / 13卷 / 06期
关键词：
D O I：
10.1158/1078-0432.CCR-06-2659
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Metastasis to the brain is prevalent in solid tumors and lymphomas, and is associated with shortened survival. The brain is regarded as a sanctuary site for metastatic tumor cells where they exist partially protected from drugs by the blood-tumor barrier. Model systems for brain metastasis have been developed and are now yielding mechanistic insights into the roles of angiogenesis, energy metabolism, the Her-2 and Stat3 signaling pathways, and dormancy. Specific, new approaches to combat brain metastatic disease are needed.
引用
收藏
页码：1656 / 1662
页数：7
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