18F-Facbc in Prostate Cancer: A Systematic Review and Meta-Analysis

被引：30

作者：

Laudicella, Riccardo ^{[1
]}

Albano, Domenico ^{[2
]}

Alongi, Pierpaolo ^{[3
]}

Argiroffi, Giovanni ^{[4
]}

Bauckneht, Matteo ^{[5
]}

Baldari, Sergio ^{[1
]}

Bertagna, Francesco ^{[2
]}

Boero, Michele ^{[6
]}

De Vincentis, Giuseppe ^{[7
]}

Del Sole, Angelo ^{[4
]}

Rubini, Giuseppe ^{[8
]}

Fantechi, Lorenzo ^{[9
]}

Frantellizzi, Viviana ^{[10
]}

Ganduscio, Gloria ^{[3
]}

Guglielmo, Priscilla ^{[6
]}

Nappi, Anna Giulia ^{[8
]}

Evangelista, Laura ^{[11
]}

机构：

[1] Univ Messina, Dept Biomed & Dent Sci & Morphofunct Imaging, Nucl Med Unit, I-98125 Messina, Italy

[2] Univ Brescia & Spedali Civili Brescia, Dept Nucl Med, I-25123 Brescia, Italy

[3] Fdn Ist G Giglio, Unit Nucl Med, I-90015 Cefalu, Italy

[4] Univ Milan, Dept Hlth Sci, I-20142 Milan, Italy

[5] IRCCS Policlin San Martino, Nucl Med Unit, I-16132 Genoa, Italy

[6] AO Brotzu, Nucl Med Unit, I-09134 Cagliari, Italy

[7] Sapienza Univ Rome, Dept Radiol Sci Oncol & Anat Pathol, I-00161 Rome, Italy

[8] Univ Bari Aldo Moro, Dept Interdisciplinary Med, Nucl Med Unit, I-70124 Bari, Italy

[9] Univ Pisa, Nucl Med Unit, Dept New Technol & Translat Res Med & Surg, I-56126 Pisa, Italy

[10] Sapienza Univ Rome, Dept Mol Med, I-00185 Rome, Italy

[11] Veneto Inst Oncol IOV IRCCS, Nucl Med Unit, I-35128 Padua, Italy

来源：

CANCERS | 2019年 / 11卷 / 09期

关键词：

prostate cancer; F-18-FACBC; PET/CT; recurrence; meta-analysis; review; ANTI-1-AMINO-3-F-18-FLUOROCYCLOBUTANE-1-CARBOXYLIC ACID; BIOCHEMICAL RECURRENCE; RADICAL PROSTATECTOMY; MULTIPARAMETRIC MRI; PET/CT; PERFORMANCE; TOMOGRAPHY; EXPERIENCE; CARCINOMA; DIAGNOSIS;

D O I：

10.3390/cancers11091348

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Trans-1-amino-3-F-18-fluorocyclobutanecarboxylic-acid (anti-[F-18]-FACBC) has been approved for the detection of prostate cancer (PCa) in patients with elevated prostate-specific-antigen following prior treatment. This review and meta-analysis aimed to investigate the diagnostic performance of F-18-FACBC positron emission tomography/computed-tomography (PET/CT) in the detection of primary/recurrent PCa. A bibliographic search was performed including several databases, using the following terms: "FACBC"/"fluciclovine" AND "prostate cancer"/"prostate" AND "PET"/"Positron Emission Tomography". Fifteen and 9 studies were included in the systematic reviews and meta-analysis, respectively. At patient-based analysis, the pooled sensitivity and specificity of F-18-FACBC-PET/CT for the assessment of PCa were 86.3% and 75.9%, respectively. The pooled diagnostic odds-ratio value was 16.453, with heterogeneity of 30%. At the regional-based-analysis, the pooled sensitivity of F-18-FACBC-PET/CT for the evaluation of primary/recurrent disease in the prostatic bed was higher than in the extra-prostatic regions (90.4% vs. 76.5%, respectively); conversely, the pooled specificity was higher for the evaluation of extra-prostatic region than the prostatic bed (89% vs. 45%, respectively). F-18-FACBC-PET/CT seems to be promising in recurrent PCa, particularly for the evaluation of the prostatic bed. Additional studies to evaluate its utility in clinical routine are mandatory.

引用

页数：17

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