Synthesis of [C-11]methyl ketones via [C-11]methylation of dithiane intermediates

被引：0
|
作者：
Elsinga, PH
Fluks, E
Franssen, EJF
Visser, GM
Vaalburg, W
机构：
[1] PET-Center, Groningen University Hospital, 9700 RB Groningen
来源：
APPLIED RADIATION AND ISOTOPES | 1996年 / 47卷 / 01期
关键词：
D O I：
10.1016/0969-8043(95)00248-0
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A versatile synthetic route to obtain [C-11]methyl ketones from aldehydes is described. Test reactions with [C-11]CH3I on the model compounds 2-methyl- and 2-cyclohexyl- 1,3-dithiane followed by oxidation with N-bromosuccinimide gave almost quantitative radiochemical yields. Reaction of [C-11]CH3I with 2-phenylethyl-1,3-dithiane yielded the corresponding [C-11]methyl ketone in 80% radiochemical yield together with an unidentified side-product on oxidation with N-bromosuccinimide.
引用
收藏
页码：57 / 59
页数：3
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