Graphene Oxide-Based Biosensors for Liquid Biopsies in Cancer Diagnosis

被引：22
|
作者：
Chen, Shiue-Luen [1 ,2 ]
Chen, Chong-You [1 ,2 ]
Hsieh, Jason Chia-Hsun [3 ]
Yu, Zih-Yu [1 ]
Cheng, Sheng-Jen [1 ,2 ]
Hsieh, Kuan Yu [1 ,2 ]
Yang, Jia-Wei [1 ,2 ]
Kumar, Priyank, V [4 ]
Lin, Shien-Fong [1 ,2 ]
Chen, Guan-Yu [2 ,5 ]
机构：
[1] Natl Chiao Tung Univ, Dept Elect & Comp Engn, Hsinchu 300, Taiwan
[2] Natl Chiao Tung Univ, Coll Elect & Comp Engn, Inst Biomed Engn, Hsinchu 300, Taiwan
[3] Chang Gung Mem Hosp Linkou, Dept Internal Med, Div Haematol Oncol, Taoyuan 333, Taiwan
[4] Univ New South Wales, Sch Chem Engn, Sydney, NSW 2052, Australia
[5] Natl Chiao Tung Univ, Dept Biol Sci & Technol, Hsinchu 300, Taiwan
来源：
NANOMATERIALS | 2019年 / 9卷 / 12期
关键词：
liquid biopsy; circulating tumor cells; circulating tumor DNA; exosome; graphene oxide; CIRCULATING TUMOR-CELLS; DENSITY-GRADIENT SEPARATION; PEPTIDE NUCLEIC-ACID; TRANSFERRIN RECEPTOR; SENSITIVE DETECTION; EXOSOME ISOLATION; DNA; CAPTURE; AMPLIFICATION; MUTATION;
D O I：
10.3390/nano9121725
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Liquid biopsies use blood or urine as test samples, which are able to be continuously collected in a non-invasive manner. The analysis of cancer-related biomarkers such as circulating tumor cells (CTCs), circulating tumor DNA (ctDNA), microRNA, and exosomes provides important information in early cancer diagnosis, tumor metastasis detection, and postoperative recurrence monitoring assist with clinical diagnosis. However, low concentrations of some tumor markers, such as CTCs, ctDNA, and microRNA, in the blood limit its applications in clinical detection and analysis. Nanomaterials based on graphene oxide have good physicochemical properties and are now widely used in biomedical detection technologies. These materials have properties including good hydrophilicity, mechanical flexibility, electrical conductivity, biocompatibility, and optical performance. Moreover, utilizing graphene oxide as a biosensor interface has effectively improved the sensitivity and specificity of biosensors for cancer detection. In this review, we discuss various cancer detection technologies regarding graphene oxide and discuss the prospects and challenges of this technology.
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页数：17
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