Frailty as a Predictor of Mortality in Late-Life Depression: A Prospective Clinical Cohort Study

被引:18
作者
Arts, Matheus H. L. [1 ,2 ,3 ]
van den Berg, Karen S. [1 ,4 ]
Marijnissen, Radboud M. [1 ,5 ]
de Jonge, Linda [2 ]
Hegeman, Annette J. M. [4 ]
Collard, Rose M. [6 ]
Comijs, Hannie C. [7 ]
Aprahamian, Ivan [8 ]
Naarding, Paul [9 ]
Voshaar, Richard C. Oude [1 ]
机构
[1] Univ Groningen, Univ Med Ctr Groningen, Univ Ctr Psychiat, Groningen, Netherlands
[2] Mental Hlth Ctr GGZ Westelijk Noord Brabant, Dept Old Age Psychiat, Halsteren, Netherlands
[3] Tilburg Univ, Sch Social & Behav Sci, Tranzo, Tilburg, Netherlands
[4] St Antonius Hosp, Dept Psychiat, Nieuwegein, Netherlands
[5] Mental Hlth Ctr, Dept Old Age Psychiat, Pro Persona, Wolfheze, Netherlands
[6] Radboud Univ Nijmegen Med Ctr, Dept Psychiat, Nijmegen, Netherlands
[7] Vrije Univ Amsterdam, Med Ctr GGZinGeest, Dept Psychiat, EMGO Inst Hlth & Care Res, Amsterdam, Netherlands
[8] Univ Sao Paulo, Fac Med, Dept & Inst Psychiat, Sao Paulo, Brazil
[9] GGNet, Dept Old Age Psychiat, Apeldoorn, Netherlands
关键词
ALL-CAUSE MORTALITY; TELOMERE LENGTH; OLDER-ADULTS; VITAMIN-D; SYMPTOMATOLOGY IDS; PHYSICAL FRAILTY; INFLAMMATION; INVENTORY; METAANALYSIS; NETHERLANDS;
D O I
10.4088/JCP.20m13277
中图分类号
B849 [应用心理学];
学科分类号
040203 ;
摘要
Objective: Frailty is a clinical phenotype that predicts negative health outcomes, including mortality, and is increasingly used for risk stratification in geriatric medicine. Similar to frailty, late-life depression is also associated with increased mortality rates. Therefore, we examined whether frailty and frailty-related biomarkers predict mortality among depressed older patients. Methods: In our study of 378 older patients aged >= 60 years with a depressive disorder (DSM-IV criteria), we examined whether frailty predicts time-to-death during a 6-year follow-up using Cox proportional hazard regression analyses adjusted for confounders. Baseline data were collected from 2007 to September 2010. Frailty was defined according to the Fried Frailty Phenotype criteria (muscle weakness, slowness, exhaustion, low activity level, unintended weight loss). Similarly, we examined the predictive value of 3 inflammatory markers, vitamin D level, and leukocyte telomere length and whether these effects were independent of the frailty phenotype. Results: During follow-up, 27 (26.2%) of 103 frail depressed patients died compared with 35 (12.7%) of 275 non-frail depressed patients (P < .001). Adjusted for confounders, the number of frailty components was associated with an increased mortality rate (hazard ratio = 1.38 [95% CI, 1.06-1.78], P = .015). All biomarkers except for interleukin 6 were prospectively associated with mortality, but only higher levels of high-sensitivity C-reactive protein and lower levels of vitamin D were independent of frailty associated with mortality. Conclusions: In late-life depression, frailty identifies older patients at increased risk of adverse negative health outcomes. Therefore, among frail depressed patients, treatment models that include frailty-specific interventions might reduce mortality rates.
引用
收藏
页数:8
相关论文
共 48 条
[1]   Depression, Frailty, and All-Cause Mortality: A Cohort Study of Men Older than 75 Years [J].
Almeida, Osvaldo P. ;
Hankey, Graeme J. ;
Yeap, Bu B. ;
Golledge, Jonathan ;
Norman, Paul E. ;
Flicker, Leon .
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION, 2015, 16 (04) :296-300
[2]   Leucocyte telomere length is no molecular marker of physical frailty in late-life depression [J].
Arts, Matheus H. L. ;
Collard, Rose M. ;
Comijs, Hannie C. ;
de Jonge, Linda ;
Penninx, Brenda W. J. H. ;
Naarding, Paul ;
Kok, Rob M. ;
Voshaar, Richard C. Oude .
EXPERIMENTAL GERONTOLOGY, 2018, 111 :229-234
[3]   Relationship Between Physical Frailty and Low-Grade Inflammation in Late-Life Depression [J].
Arts, Matheus H. L. ;
Collard, Rose M. ;
Comijs, Hannie C. ;
Naude, Petrus J. W. ;
Risselada, Roelof ;
Naarding, Paul ;
Voshaar, Richard C. Oude .
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2015, 63 (08) :1652-1657
[4]   EARLY DETECTION OF HARMFUL ALCOHOL-CONSUMPTION - COMPARISON OF CLINICAL, LABORATORY, AND SELF-REPORT SCREENING PROCEDURES [J].
BABOR, TF ;
KRANZLER, HR ;
LAUERMAN, RJ .
ADDICTIVE BEHAVIORS, 1989, 14 (02) :139-157
[5]   Frailty as a predictor of mortality in older adults within 5 years of psychiatric admission [J].
Benraad, Carolien E. M. ;
Haaksma, Miriam L. ;
Karlietis, Mieke H. J. ;
Voshaar, Richard C. Oude ;
Spijker, Jan ;
Melis, Rene J. F. ;
Rikkert, Marcel G. M. Olde .
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, 2020, 35 (06) :617-625
[6]   Relevance of vitamin D in the pathogenesis and therapy of frailty [J].
Bruyere, Olivier ;
Cavalier, Etienne ;
Buckinx, Fanny ;
Reginster, Jean-Yves .
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE, 2017, 20 (01) :26-29
[7]   Frailty assessment instruments: Systematic characterization of the uses and contexts of highly-cited instruments [J].
Buta, Brian J. ;
Walston, Jeremy D. ;
Godino, Job G. ;
Park, Minsun ;
Kalyani, Rita R. ;
Xue, Qian-Li ;
Bandeen-Roche, Karen ;
Varadhan, Ravi .
AGEING RESEARCH REVIEWS, 2016, 26 :53-61
[8]   Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases [J].
Cardoso, Ana Luisa ;
Fernandes, Adelaide ;
Aguilar-Pimentel, Juan Antonio ;
de Angelis, Martin Hrabe ;
Guedes, Joana Ribeiro ;
Brito, Maria Alexandra ;
Ortolano, Saida ;
Pani, Giovambattista ;
Athanasopoulou, Sophia ;
Gonos, Efstathios S. ;
Schosserer, Markus ;
Grillari, Johannes ;
Peterson, Part ;
Tuna, Bilge Guvenc ;
Dogan, Soner ;
Meyer, Angelika ;
van Os, Ronald ;
Trendelenburg, Anne-Ulrike .
AGEING RESEARCH REVIEWS, 2018, 47 :214-277
[9]   Physical frailty: vulnerability of patients suffering from late-life depression [J].
Collard, Rose M. ;
Comijs, Hannie C. ;
Naarding, Paul ;
Voshaar, Richard C. Oude .
AGING & MENTAL HEALTH, 2014, 18 (05) :570-578
[10]   The Netherlands study of depression in older persons (NESDO); A prospective cohort study [J].
Comijs H.C. ;
Van Marwijk H.W. ;
Van Der Mast R.C. ;
Naarding P. ;
Oude Voshaar R.C. ;
Beekman A.T.F. ;
Boshuisen M. ;
Dekker J. ;
Kok R. ;
De Waal M.W.M. ;
Penninx B.W.J.H. ;
Stek M.L. ;
Smit J.H. .
BMC Research Notes, 4 (1)