Insights from a Pan India Sero-Epidemiological survey (Phenome-India Cohort) for SARS-CoV2

被引：16

作者：

Naushin, Salwa ^{[1
,2
]}

Sardana, Viren ^{[1
,2
]}

Ujjainiya, Rajat ^{[1
,2
]}

Bhatheja, Nitin ^{[1
]}

Kutum, Rintu ^{[1
,2
]}

Bhaskar, Akash Kumar ^{[1
,2
]}

Pradhan, Shalini ^{[1
]}

Prakash, Satyartha ^{[1
]}

Khan, Raju ^{[2
,3
]}

Rawat, Birendra Singh ^{[2
,4
]}

Tallapaka, Karthik Bharadwaj ^{[5
]}

Anumalla, Mahesh ^{[5
]}

Chandak, Giriraj Ratan ^{[2
,5
]}

Lahiri, Amit ^{[2
,6
]}

Kar, Susanta ^{[2
,6
]}

Mulay, Shrikant Ramesh ^{[2
,6
]}

Mugale, Madhav Nilakanth ^{[2
,6
]}

Srivastava, Mrigank ^{[2
,6
]}

Khan, Shaziya ^{[2
,6
]}

Srivastava, Anjali ^{[2
,6
]}

Tomar, Bhawana ^{[2
,6
]}

Veerapandian, Murugan ^{[2
,7
]}

Venkatachalam, Ganesh ^{[2
,7
]}

Vijayakumar, Selvamani Raja ^{[7
]}

Agarwal, Ajay ^{[2
,8
]}

Gupta, Dinesh ^{[8
]}

Halami, Prakash M. ^{[2
,9
]}

Peddha, Muthukumar Serva ^{[2
,9
]}

Sundaram, Gopinath M. ^{[2
,9
]}

Veeranna, Ravindra P. ^{[2
,9
]}

Pal, Anirban ^{[2
,10
]}

Agarwal, Vinay Kumar ^{[10
]}

Maurya, Anil Ku ^{[10
]}

Singh, Ranvijay Kumar ^{[2
,11
]}

Raman, Ashok Kumar ^{[11
]}

Anandasadagopan, Suresh Kumar ^{[2
,12
]}

Karuppanan, Parimala ^{[12
]}

Venkatesan, Subramanian ^{[2
,12
]}

Sardana, Harish Kumar ^{[13
]}

Kothari, Anamika ^{[13
]}

Jain, Rishabh ^{[2
,13
]}

Thakur, Anupama ^{[2
,13
]}

Parihar, Devendra Singh ^{[2
,13
]}

Saifi, Anas ^{[2
,13
]}

Kaur, Jasleen ^{[2
,13
]}

Kumar, Virendra ^{[13
]}

Mishra, Avinash ^{[2
,14
]}

Gogeri, Iranna ^{[2
,15
]}

Rayasam, Geethavani ^{[2
,16
]}

Singh, Praveen ^{[1
,2
]}

机构：

[1] CSIR, Inst Genom & Integrat Biol, New Delhi, India

[2] Acad Sci & Innovat Res AcSIR, Ghaziabad, India

[3] CSIR, Adv Mat & Proc Res Inst, Bhopal, India

[4] CSIR, Cent Bldg Res Inst, Roorkee, Uttar Pradesh, India

[5] CSIR Ctr Cellular Mol Biol, Hyderabad, India

[6] CSIR, Cent Drug Res Inst, Lucknow, Uttar Pradesh, India

[7] CSIR, Cent Electrochem Res Inst, Karaikkudi, Tamil Nadu, India

[8] CSIR, Cent Elect Engn Res Inst, Pilani, Rajasthan, India

[9] CSIR, Cent Food Technol Res Inst, Mysore, Karnataka, India

[10] CSIR, Cent Inst Med Aromat Plants, Lucknow, Uttar Pradesh, India

[11] CSIR, Cent Inst Min & Fuel Res, Dhanbad, Bihar, India

[12] CSIR, Cent Leather Res Inst, Chennai, Tamil Nadu, India

[13] CSIR, Cent Sci Instruments Org, Chandigarh, India

[14] CSIR, Cent Salt Marine Chem Res Inst, Bhavnagar, Gujarat, India

[15] CSIR, Fourth Paradigm Inst, Bengaluru, India

[16] CSIR Headquarters, Rafi Marg, New Delhi, India

[17] CSIR, Inst Himalayan Bioresource Technol, Palampur, Himachal Prades, India

[18] CSIR, Indian Inst Chem Biol, Kolkata, India

[19] CSIR, Indian Inst Chem Technol, Hyderabad, India

[20] CSIR, Indian Inst Integrat Med, Jammu, India

[21] CSIR, Indian Inst Petr, Dehra Dun, Uttarakhand, India

[22] CSIR, Inst Minerals & Mat Technol, Bhubaneswar, India

[23] CSIR, Inst Microbial Technol, Chandigarh, India

[24] CSIR, Natl Aerosp Labs, Bengaluru, India

[25] CSIR, Natl Chem Lab, Pune, Maharashtra, India

[26] CSIR, Natl Environm Engn Res Inst, Nagpur, Maharashtra, India

[27] CSIR, North East Inst Sci & Technol, Jorhat, Assam, India

[28] CSIR, Natl Geophys Res Inst, Hyderabad, India

[29] CSIR, Natl Inst Interdisciplinary Sci & Technol, Thiruvananthapuram, Kerala, India

[30] CSIR, Natl Inst Oceanog, Panaji, Goa, India

[31] CSIR, Natl Inst Sci Technol & Dev Studies, New Delhi, India

[32] CSIR, Natl Phys Lab, New Delhi, India

来源：

ELIFE | 2021年 / 10卷

关键词：

COVID-19; INFECTION;

D O I：

10.7554/eLife.66537

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

To understand the spread of SARS-CoV2, in August and September 2020, the Council of Scientific and Industrial Research (India) conducted a serosurvey across its constituent laboratories and centers across India. Of 10,427 volunteers, 1058 (10.14%) tested positive for SARS-CoV2 anti-nucleocapsid (anti-NC) antibodies, 95% of which had surrogate neutralization activity. Three-fourth of these recalled no symptoms. Repeat serology tests at 3 (n = 607) and 6 (n = 175) months showed stable anti-NC antibodies but declining neutralization activity. Local seropositivity was higher in densely populated cities and was inversely correlated with a 30-day change in regional test positivity rates (TPRs). Regional seropositivity above 10% was associated with declining TPR. Personal factors associated with higher odds of seropositivity were high-exposure work (odds ratio, 95% confidence interval, p value: 2.23, 1.92-2.59, <0.0001), use of public transport (1.79, 1.43-2.24, <0.0001), not smoking (1.52, 1.16-1.99, 0.0257), non-vegetarian diet (1.67, 1.41-1.99, <0.0001), and B blood group (1.36, 1.15-1.61, 0.001).

引用

页数：13

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