The Rise and Fall of Hydroxychloroquine and Chloroquine in COVID-19

被引:8
作者
Aljadeed, Rana [1 ]
机构
[1] King Saud Univ, Coll Pharm, Riyadh, Saudi Arabia
关键词
covid-19; SARS-Cov-2; coronavirus; hydroxychloroquine; chloroquine; DRUG; AZITHROMYCIN; INFECTION;
D O I
10.1177/0897190021997399
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
On March 11th, the World Health Organization (WHO) announced the unprecedented outbreak of "severe acute respiratory syndrome coronavirus 2" (SARS-CoV-2) to be a pandemic. Thus far, COVID-19 has infected over 58,229,138 individuals and caused 1,382,106 deaths worldwide. This has led to the re-purposing of available drugs under "off-label" use-drugs such as hydroxychloroquine and chloroquine. Both drugs have since been evaluated for their ability to treat COVID-19. Here, we summarize recent evidence regarding the use of hydroxychloroquine and chloroquine in hospitalized patients with COVID-19. All data is current as of November 23, 2020.
引用
收藏
页码:971 / 978
页数:8
相关论文
共 53 条
  • [1] Alhazzani W, 2020, CRIT CARE MED, V48, pE440, DOI [10.1007/s00134-020-06022-5, 10.1097/CCM.0000000000004363]
  • [2] [Anonymous], CHLOR
  • [3] Hydroxychloroquine for Treatment of SARS-CoV-2 Infection? Improving Our Confidence in a Model-Based Approach to Dose Selection
    Arnold, Samuel L. M.
    Buckner, Frederick
    [J]. CTS-CLINICAL AND TRANSLATIONAL SCIENCE, 2020, 13 (04): : 642 - 645
  • [4] Treatment with hydroxychloroquine, azithromycin, and combination in patients hospitalized with COVID-19
    Arshad, Samia
    Kilgore, Paul
    Chaudhry, Zohra S.
    Jacobsen, Gordon
    Wang, Dee Dee
    Huitsing, Kylie
    Brar, Indira
    Alangaden, George J.
    Ramesh, Mayur S.
    McKinnon, John E.
    O'Neill, William
    Zervos, Marcus
    [J]. INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2020, 97 : 396 - 403
  • [5] Insights into the Recent 2019 Novel Coronavirus (SARS-CoV-2) in Light of Past Human Coronavirus Outbreaks
    Ashour, Hossam M.
    Elkhatib, Walid F.
    Rahman, Md. Masudur
    Elshabrawy, Hatem A.
    [J]. PATHOGENS, 2020, 9 (03):
  • [6] Updated guidance on the management of COVID-19: from an American Thoracic Society/European Respiratory Society coordinated International Task Force (29 July 2020)
    Bai, Chunxue
    Chotirmall, Sanjay H.
    Rello, Jordi
    Alba, George A.
    Ginns, Leo C.
    Krishnan, Jerry A.
    Rogers, Robert
    Bendstrup, Elisabeth
    Burgel, Pierre-Regis
    Chalmers, James D.
    Chua, Abigail
    Crothers, Kristina A.
    Duggal, Abhijit
    Kim, Yeon Wook
    Laffey, John G.
    Luna, Carlos M.
    Niederman, Michael S.
    Raghu, Ganesh
    Ramirez, Julio A.
    Riera, Jordi
    Roca, Oriol
    Tamae-Kakazu, Maximiliano
    Torres, Antoni
    Watkins, Richard R.
    Barrecheguren, Miriam
    Belliato, Mirko
    Chami, Hassan A.
    Chen, Rongchang
    Cortes-Puentes, Gustavo A.
    Delacruz, Charles
    Hayes, Margaret M.
    Heunks, Leo M. A.
    Holets, Steven R.
    Hough, Catherine L.
    Jagpal, Sugeet
    Jeon, Kyeongman
    Johkoh, Takeshi
    Lee, May M.
    Liebler, Janice
    McElvaney, Gerry N.
    Moskowitz, Ari
    Oeckler, Richard A.
    Ojanguren, Inigo
    O'Regan, Anthony
    Pletz, Mathias W.
    Rhee, Chin Kook
    Schultz, Marcus J.
    Storti, Enrico
    Strange, Charlie
    Thomson, Carey C.
    [J]. EUROPEAN RESPIRATORY REVIEW, 2020, 29 (157) : 1 - 15
  • [7] Infectious Diseases Society of America Guidelines on the Treatment and Management of Patients With COVID-19 (April 2020)
    Bhimraj, Adarsh
    Morgan, Rebecca L.
    Shumaker, Amy Hirsch
    Lavergne, Valery
    Baden, Lindsey
    Cheng, Vincent Chi-Chung
    Edwards, Kathryn M.
    Gandhi, Rajesh
    Muller, William J.
    O'Horo, John C.
    Shoham, Shmuel
    Murad, M. Hassan
    Mustafa, Reem A.
    Sultan, Shahnaz
    Falck-Ytter, Yngve
    [J]. CLINICAL INFECTIOUS DISEASES, 2020, 78 (07) : e83 - e102
  • [8] Hydroxychloroquine with or without Azithromycin in Mild-to-Moderate Covid-19
    Cavalcanti, A. B.
    Zampieri, F. G.
    Rosa, R. G.
    Azevedo, L. C. P.
    Veiga, V. C.
    Avezum, A.
    Damiani, L. P.
    Marcadenti, A.
    Kawano-Dourado, L.
    Lisboa, T.
    Junqueira, D. L. M.
    de Barros e Silva, P. G. M.
    Tramujas, L.
    Abreu-Silva, E. O.
    Laranjeira, L. N.
    Soares, A. T.
    Echenique, L. S.
    Pereira, A. J.
    Freitas, F. G. R.
    Gebara, O. C. E.
    Dantas, V. C. S.
    Furtado, R. H. M.
    Milan, E. P.
    Golin, N. A.
    Cardoso, F. F.
    Maia, I. S.
    Hoffmann Filho, C. R.
    Kormann, A. P. M.
    Amazonas, R. B.
    Bocchi de Oliveira, M. F.
    Serpa-Neto, A.
    Falavigna, M.
    Lopes, R. D.
    Machado, F. R.
    Berwanger, O.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (21) : 2041 - 2052
  • [9] Chen Jun, 2020, Zhejiang Da Xue Xue Bao Yi Xue Ban, V49, P215, DOI 10.3785/j.issn.1008-9292.2020.03.03
  • [10] Chen Z, 2020, MEDRXIV, P7, DOI 10.1101/2020.03.22.20040758