The Cucurbit[7]Uril-Based Supramolecular Chemistry for Reversible B/Z-DNA Transition

被引:30
作者
Wang, Shao-Ru [1 ]
Wang, Jia-Qi [1 ]
Xu, Guo-Hua [2 ]
Wei, Lai [1 ]
Fu, Bo-Shi [1 ]
Wu, Ling-Yu [1 ]
Song, Yan-Yan [1 ]
Yang, Xi-Ran [3 ]
Li, Conggang [2 ]
Liu, Si-Min [3 ]
Zhou, Xiang [1 ]
机构
[1] Wuhan Univ, Minist Educ, Key Lab Biomed Polymers, Coll Chem & Mol Sci, Wuhan 430072, Hubei, Peoples R China
[2] Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Key Lab Magnet Resonance Biol Syst, Wuhan 430071, Hubei, Peoples R China
[3] Wuhan Univ Sci & Technol, Coll Chem Engn & Technol, Wuhan 430081, Hubei, Peoples R China
基金
美国国家科学基金会;
关键词
cucurbit[7]uril; reversible B/Z-DNA transitions; spermine; supramolecular chemistry; HANDED Z-DNA; B-DNA; CIRCULAR-DICHROISM; BINDING; PROTEIN; PAIR; AFFINITY; OLIGONUCLEOTIDES; TRANSCRIPTION; CUCURBITURIL;
D O I
10.1002/advs.201800231
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
As a left-handed helical structure, Z-DNA is biologically active and it may be correlated with transcription and genome stability. Until recently, it remained a significant challenge to control the B/Z-DNA transition under physiological conditions. The current study represents the first to reversibly control B/Z-DNA transition using cucurbit[7]uril-based supramolecular approach. It is demonstrated that cucurbit[7]uril can encapsulate the central butanediamine moiety [HN(CH2)(4)NH] and reverses Z-DNA caused by spermine back to B-DNA. The subsequent treatment with 1-adamantanamine disassembles the cucurbit[7]uril/spermine complex and readily induces reconversion of B- into Z-DNA. The DNA conformational change is unequivocally demonstrated using different independent methods. Direct evidence for supramolecular interactions involved in DNA conformational changes is further provided. These findings can therefore open a new route to control DNA helical structure in a reversible way.
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页数:9
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