Characterization and in vitro cellular uptake of PEG coated iron oxide nanoparticles as MRI contrast agent

被引：22
作者：
Chen, Y. J. [1 ,2 ]
Tao, J. [1 ,2 ]
Xiong, F. [2 ]
Zhu, J. B. [1 ]
Gu, N. [2 ]
Geng, K. K. [1 ,2 ]
机构：
[1] China Pharmaceut Univ, Pharmaceut Res Inst, Nanjing 210009, Peoples R China
[2] Southeast Univ, State Key Lab Bioelect, Jiangsu Lab Biomat & Devices, Sch Biol Sci & Med Engn, Nanjing 210009, Peoples R China
来源：
PHARMAZIE | 2010年 / 65卷 / 07期
基金：
中国国家自然科学基金;
关键词：
PARTICLE-SIZE; POLY(ETHYLENE GLYCOL); MAGNETITE NANOPARTICLES; POLYMERIC NANOPARTICLES; FE3O4; NANOPARTICLES; NANOCRYSTALS; CELLS; ACCUMULATION; DISPERSIONS; RELAXIVITY;
D O I：
10.1691/ph.2010.9372
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Monodisperse magnetic iron oxide nanoparticles (MNPs), coated with PEG at different molecular weight, were prepared via self-assembly method. The particle diameters were measured by dynamic light scattering and transmission electron microscope. Increasing the molecular weight of PEG in the coating polymer increased the overall particles diameter. As coating thickness increased, the saturation magnetization (Ms) and T-2 relaxivity decreased. The interactions of these MNPs with macrophage cells were also investigated. The results showed that cellular uptakes of MNPs depended on nanoparticle concentration and surface chemistry. The results of this study will have implications on the chemical design of nanomaterials for bio-imaging and bio-detection.
引用
收藏
页码：481 / 486
页数：6
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