Biochemical heterogeneity of Alzheimer's disease

被引：1

作者：

Shoji, M ^{[1
]}

Harigaya, Y ^{[1
]}

机构：

[1] Gunma Univ, Sch Med, Dept Neurol, Maebashi, Gumma 371, Japan

来源：

NEUROPATHOLOGY | 1998年 / 18卷 / 01期

关键词：

Alzheimer's disease; amyloid beta protein; biochemical heterogeneity;

D O I：

10.1111/j.1440-1789.1998.tb00088.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Amyloid beta protein (A beta) amyloid deposition is an important early event in the evolution of Alzheimer's disease (AD) pathology. Serial extraction studies of AD brains showed that a large amount of modified A beta (4, 3.7 and 3 kDa A beta species) was accumulated as forms with differing solubilities, Immunostaining using specific antibodies to the N and C terminus of A beta showed that N-terminally modified A beta ending at 42A were predominant in senile plaques. Quantitative assay of A beta in AD brain revealed that A beta ending at 40 V were correlated with vascular amyloids and that A beta ending at 42(43) were related with senile plaque amyloids. The site of A beta deposits may be determined by the heterogeneous length of the C terminus A beta. The amount of A beta amyloids may be correlated with N-terminal modification of A beta. Thus, heterogeneity of A beta species is a crucial biochemical factor of AD pathogenesis.

引用

页码：116 / 120

页数：5

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