Anti-signal Recognition Particle Antibody-positive Necrotizing Myopathy with Secondary Cardiomyopathy: The First Myocardial Biopsy- and Multimodal Imaging-proven Case

被引：14

作者：

Takeguchi-Kikuchi, Shiori ^{[1
]}

Hayasaka, Taiki ^{[2
]}

Katayama, Takayuki ^{[1
]}

Kano, Kohei ^{[1
]}

Takahashi, Kae ^{[1
]}

Saito, Tsukasa ^{[1
]}

Sawada, Jun ^{[1
]}

Minoshima, Akiho ^{[2
]}

Sakamoto, Naka ^{[2
]}

Akasaka, Kazumi ^{[2
]}

Miyokawa, Naoyuki ^{[3
]}

Nishino, Ichizo ^{[4
]}

Ishibashi-Ueda, Hatsue ^{[5
]}

Hasebe, Naoyuki ^{[1
,2
]}

机构：

[1] Asahikawa Med Univ, Dept Internal Med 1, Div Neurol, Asahikawa, Hokkaido, Japan

[2] Asahikawa Med Univ, Dept Internal Med 1, Div Cardiol, Asahikawa, Hokkaido, Japan

[3] Asahikawa Med Univ, Dept Clin Pathol, Asahikawa, Hokkaido, Japan

[4] Natl Ctr Neurol & Psychiat, Natl Inst Neurosci, Dept Neuromuscular Res, Kodaira, Tokyo, Japan

[5] Natl Cerebral & Cardiovasc Ctr, Dept Pathol, Suita, Osaka, Japan

来源：

INTERNAL MEDICINE | 2019年 / 58卷 / 21期

关键词：

anti-signal recognition particle (SRP) antibody; necrotizing myopathy; cardiomyopathy; myocardial biopsy; positron-emission tomography (PET); AUTOANTIBODIES; ASSOCIATION;

D O I：

10.2169/internalmedicine.2564-18

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 69-year-old Japanese woman was admitted to our hospital with progressive muscle weakness and dysphagia. She was taking pitavastatin for dyslipidemia. Her serum creatine kinase was 6,300 U/L. Pitavastatin was stopped. but her symptoms deteriorated, and cardiac congestion appeared. A muscle biopsy showed necrotizing myopathy (NM), and anti-signal recognition particle (SRP) antibody was positive. F-18-fluorodeoxyglucose-positron emission tomography showed an abnormal uptake, and magnetic resonance imaging showed abnormal gadolinium enhancement in the left ventricular wall. An endomyocardial biopsy revealed inflammatory cardiomyopathy. Steroid, tacrolimus, and intravenous immunoglobulins were effective against the symptoms. This is the first case of biopsy-proven secondary cardiomyopathy due to anti-SRP-positive NM.

引用

页码：3189 / 3194

页数：6

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