Carbapenemase-producing Klebsiella pneumoniae: molecular and genetic decoding

被引：437

作者：

Chen, Liang ^{[1
]}

Mathema, Barun ^{[1
,2
]}

Chavda, Kalyan D. ^{[1
]}

DeLeo, Frank R. ^{[3
]}

Bonomo, Robert A. ^{[4
,5
,6
,7
]}

Kreiswirth, Barry N. ^{[1
]}

机构：

[1] Rutgers State Univ, New Jersey Med Sch, Publ Res Inst, TB Ctr, Newark, NJ 07103 USA

[2] Columbia Univ, Dept Epidemiol, Mailman Sch Publ Hlth, New York, NY 10032 USA

[3] NIAID, Lab Human Bacterial Pathogenesis, Rocky Mt Labs, NIH, Hamilton, MT 59840 USA

[4] Vet Affairs Med Ctr, Louis Stokes Cleveland Dept, Res Serv, Cleveland, OH 44106 USA

[5] Case Western Reserve Univ, Dept Med, Cleveland, OH 44106 USA

[6] Case Western Reserve Univ, Dept Pharmacol, Cleveland, OH 44106 USA

[7] Case Western Reserve Univ, Dept Mol Biol & Microbiol, Cleveland, OH 44106 USA

来源：

TRENDS IN MICROBIOLOGY | 2014年 / 22卷 / 12期

基金：

美国国家卫生研究院;

关键词：

Klebsiella pneumoniae carbapenemase; carbapenem-resistant; ST258; COMPLETE NUCLEOTIDE-SEQUENCE; COMPLETE GENOME SEQUENCE; BETA-LACTAMASE; ANTIBIOTIC-RESISTANCE; NEW-JERSEY; BLA(KPC-2) GENE; 1ST DESCRIPTION; PLASMIDS; DISSEMINATION; STRAINS;

D O I：

10.1016/j.tim.2014.09.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Klebsiella pneumoniae carbapenemases (KPCs) were first identified in 1996 in the USA. Since then, regional outbreaks of KPC-producing K. pneumoniae (KPC-Kp) have occurred in the USA, and have spread internationally. Dissemination of bla(KPC) involves both horizontal transfer of bla(KPC) genes and plasmids, and clonal spread. Of epidemiological significance, the international spread of KPC-producing K. pneumoniae is primarily associated with a single multilocus sequence type (ST), ST258, and its related variants. However, the molecular factors contributing to the success of ST258 largely remain unclear. In this review, we discuss the recent progresses in understanding KPC-producing K. pneumoniae that are contributing to our knowledge of plasmid and genome composition and structure among the KPC epidemic clone, and we identify possible factors that influence its epidemiological success.

引用

页码：686 / 696

页数：11

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