Tetracationic compounds based on 1,4-diazabicyclo[2.2.2]octane: antibacterial activity and reactions with N-containing nucleophiles

被引：3

作者：

Burakova, E. A. ^{[1
]}

Saranina, I. V. ^{[1
]}

Tikunova, N. V. ^{[1
]}

Sil'nikov, V. N. ^{[1
]}

机构：

[1] Russian Acad Sci, Novosibirsk Inst Chem Biol & Fundamental Med, Siberian Branch, 8 Prosp Akad Lavrenteva, Novosibirsk 630090, Russia

来源：

RUSSIAN CHEMICAL BULLETIN | 2015年 / 64卷 / 06期

关键词：

tetracationic compounds; quaternary ammonium compounds (QAC); 1,4-di-azabicyclo[2.2.2]octane (DABCO); antibacterial activities; ANTIMICROBIAL ACTIVITIES; QUATERNARY; SALTS;

D O I：

10.1007/s11172-015-1023-2

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Antibacterial activity of tetracationic compounds based on 1,4-diazabicyclo[2.2.2]octane (DABCO) bis-quaternary salts with dodecyl substituents bound by linker groups containing four carbon atoms was studied. All the compounds exhibited activity against the test-strains under study. The gram-positive culture S. aureus was found to be the most sensitive to the influence of compounds in question. The highest activity against S. aureus was exhibited by the compounds containing a but-2-yne or a butane linker; their efficiency exceeded that of the reference compound, antibiotic Ciprofloxacin. For the gram-negative culture P. aeruginosa, the highest activity was exhibited by the compound containing a but-2-yne linker. The compounds with a but-2-yne or a butane linker are stable in the presence of nitrogen-containing nucleophiles, which makes them promising for further studies.

引用

页码：1400 / 1405

页数：6

共 27 条

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