Intracellular Ca2+ Signaling in Skeletal Muscle: Decoding a Complex Message

被引:32
作者
Chin, Eva R. [1 ]
机构
[1] Univ Maryland, Dept Kinesiol, Sch Publ Hlth, College Pk, MD 20742 USA
来源
EXERCISE AND SPORT SCIENCES REVIEWS | 2010年 / 38卷 / 02期
基金
加拿大自然科学与工程研究理事会; 美国国家卫生研究院; 英国医学研究理事会;
关键词
calcium; gene expression; fatigue; metabolic regulation; muscle adaptation; intracellular signaling; STRETCH-ACTIVATED CHANNELS; CALCIUM-IONS; MOTOR UNITS; ENTRY; FATIGUE; PATHWAY; FIBERS; KINASE; CALCINEURIN; EXPRESSION;
D O I
10.1097/JES.0b013e3181d495d2
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
CHIN, E. R. Intracellular Ca2+ signaling in skeletal muscle: decoding a complex message. Exerc. Sport Sci. Rev., Vol. 38, No. 2, pp. 76-85, 2010. Intracellular calcium (Ca2+) plays an important role in regulating muscle force production, metabolism, and muscle gene expression. It is hypothesized that the precise pattern of Ca2+ oscillations, determined by the Ca2+ channels activated and the contributing Ca2+ pools, controls the coupling between neural activation, force production, cellular energetics, and gene expression. The physiological and cellular coordination between these events will be discussed.
引用
收藏
页码:76 / 85
页数:10
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