The Presence of Morphine as Heroin Metabolites in Placental Tissue and Fetus: Case Report

被引：0
作者：
Nikolic, Slobodan [1 ]
Labudovic, Jelena Micic [1 ]
Lukic, Vera [1 ]
Zivkovic, Vladimir [1 ]
机构：
[1] Univ Belgrade, Sch Med, Inst Forens Med, Belgrade, Serbia
来源：
SRPSKI ARHIV ZA CELOKUPNO LEKARSTVO | 2014年 / 142卷 / 9-10期
关键词：
heroin; morphine; placenta; meconium; autopsy; NEONATAL OUTCOMES; DRUG EXPOSURE; MECONIUM; BUPRENORPHINE; PREGNANCY; ABUSE;
D O I：
10.2298/SARH1410610N
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Introduction Females who have developed addiction to heroin also abuse it during pregnancy. Heroin can be detected in the fetal blood-flow already an hour after maternal i.v. injection. Heroin metabolites enter the fetal blood-flow through the placental barrier by passive transport. Case Outline We present a 27-year-old female in the 5th month of pregnancy that had a miscarriage. Chemo-toxicological analysis (gas chromatography with mass spectrometry - GC/MS), showed the presence of morphine in the fetal liver (31.92 ng/g), placenta (27.94 ng/g) and meconium (136.33 ng/g). The analysis did not show the presence of 6-monoacetylmorphine. Conclusion In all cases when the autopsy of fetus or newborn is performed, with mother suspected as i.v. heroin abuser, chemotoxicological placental analysis, placenta and meconium should be also done
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页码：610 / 613
页数：4
相关论文
共 15 条
  • [1] Quantification of fatty acid ethyl esters (FAEE) and ethyl glucuronide (EtG) in meconium from newborns for detection of alcohol abuse in a maternal health evaluation study
    Bakdash, Abdulsallam
    Burger, Pascal
    Goecke, Tamme W.
    Fasching, Peter A.
    Reulbach, Udo
    Bleich, Stefan
    Hastedt, Martin
    Rothe, Michael
    Beckmann, Matthias W.
    Pragst, Fritz
    Kornhuber, Johannes
    [J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2010, 396 (07) : 2469 - 2477
  • [2] Brinkmann B, 2004, HDB GERICHTLICHE MED
  • [3] Byard RW, 2010, SUDDEN DEATH YOUNG
  • [4] Maternal Methadone Dose, Placental Methadone Concentrations, and Neonatal Outcomes
    de Castro, Ana
    Jones, Hendree E.
    Johnson, Rolley E.
    Gray, Teresa R.
    Shakleya, Diaa M.
    Huestis, Marilyn A.
    [J]. CLINICAL CHEMISTRY, 2011, 57 (03) : 449 - 458
  • [5] Drugs of abuse testing in meconium
    Gareri, J
    Klein, J
    Koren, G
    [J]. CLINICA CHIMICA ACTA, 2006, 366 (1-2) : 101 - 111
  • [6] (R)- and (S)-methadone and buprenorphine concentration ratios in maternal and umbilical cord plasma following chronic maintenance dosing in pregnancy
    Gordon, Andrea L.
    Lopatko, Olga V.
    Somogyi, Andrew A.
    Foster, David J. R.
    White, Jason M.
    [J]. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2010, 70 (06) : 895 - 902
  • [7] Fatty acid ethyl esters (FAEEs) as markers for alcohol in meconium: method validation and implementation of a screening program for prenatal drug exposure
    Hastedt, Martin
    Krumbiegel, Franziska
    Gapert, Rene
    Tsokos, Michael
    Hartwig, Sven
    [J]. FORENSIC SCIENCE MEDICINE AND PATHOLOGY, 2013, 9 (03) : 287 - 295
  • [8] Drug abuse's smallest victims: in utero drug exposure
    Huestis, MA
    Choo, RE
    [J]. FORENSIC SCIENCE INTERNATIONAL, 2002, 128 (1-2) : 20 - 30
  • [9] Correlations of Maternal Buprenorphine Dose, Buprenorphine, and Metabolite Concentrations in Meconium With Neonatal Outcomes
    Kacinko, S. L.
    Jones, H. E.
    Johnson, R. E.
    Choo, R. E.
    Huestis, M. A.
    [J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 2008, 84 (05) : 604 - 612
  • [10] Karch S.B., 2002, KARCHS PATHOLOGY DRU
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