Octacalcium phosphate (OCP) collagen composites enhance bone healing in a dog tooth extraction socket model

被引：24

作者：

Iibuchi, S. ^{[2
]}

Matsui, K. ^{[2
]}

Kawai, T. ^{[2
]}

Sasaki, K. ^{[3
]}

Suzuki, O. ^{[4
]}

Kamakura, S. ^{[1
]}

Echigo, S. ^{[2
]}

机构：

[1] Tohoku Univ, Grad Sch Biomed Engn, Bone Regenerat Engn Lab, Aoba Ku, Sendai, Miyagi 9808574, Japan

[2] Tohoku Univ, Grad Sch Dent, Dept Oral Med & Surg, Div Oral Surg, Sendai, Miyagi 9808574, Japan

[3] Nippon Meat Packers Inc, R&D Ctr, Tsukuba, Ibaraki, Japan

[4] Tohoku Univ, Grad Sch Dent, Div Craniofacial Funct Engn, Sendai, Miyagi 9808574, Japan

来源：

INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY | 2010年 / 39卷 / 02期

基金：

日本科学技术振兴机构;

关键词：

bone regeneration; octacalcium phosphate; collagen; extraction socket; dog; CALCIUM PHOSPHATES; HYDROXYAPATITE; REGENERATION; MINERALIZATION; IMPLANTATION;

D O I：

10.1016/j.ijom.2009.12.006

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

The authors have reported that a scaffold constructed of synthetic octacalcium phosphate (OCP) and porcine atelocollagen sponge (OCP/Col) enhanced bone regeneration more than sintered beta-tricalcium phosphate collagen composite or sintered hydroxyapatite collagen composite with a rat calvarial defect model. To aim for clinical application, the present study investigated whether OCP/Col Would enhance bone healing in a dog tooth extraction socket model. Six adult, male, beagle dogs were used. The tooth extraction socket model was made by extracting bilateral third maxillary incisors and the Subsequent removal of buccal bone. Disks of OCP/Col were implanted into one side of the model and the other side was untreated. The specimens were fixed I or 3 months after implantation. In radiographic analysis, the OCP/Col-treated group showed a wider range of radiopacity than the untreated control. Histologically, the OCP/Col-treated group showed more abundant newly formed bone than untreated control, and the implanted OCP was gradually resorbed. In morphometrical analysis, enlargement of the buccal alveolus in the OCP/Col group was significantly greater than ill the untreated control. This Study showed that implanted OCP/Col would be replaced by newly formed bone and OCP/Col implantation would enhance bone healing in a tooth socket model.

引用

页码：161 / 168

页数：8

共 27 条

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