Microglia: Driving critical periods and sexual differentiation of the brain

被引：59
作者：
VanRyzi, Jonathan W. [1 ,2 ]
Pickett, Lindsay A. [1 ,2 ]
McCarthy, Margaret M. [1 ,2 ]
机构：
[1] Univ Maryland, Dept Pharmacol, Sch Med, Baltimore, MD 21201 USA
[2] Univ Maryland, Sch Med, Program Neurosci, Baltimore, MD 21201 USA
来源：
DEVELOPMENTAL NEUROBIOLOGY | 2018年 / 78卷 / 06期
关键词：
microglia; sexual differentiation; sex differences; critical (sensitive) period; brain development; neuroimmunology; behavior; CENTRAL-NERVOUS-SYSTEM; EARLY-LIFE EXPERIENCE; CEREBRAL-CORTEX; NEURONAL DEATH; PREOPTIC AREA; CELL-DEATH; IN-VIVO; PERIVENTRICULAR NUCLEUS; ANTIINFLAMMATORY IL-10; SOCIAL-BEHAVIOR;
D O I：
10.1002/dneu.22569
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The proverbial role of microglia during brain development is shifting from passive members of the brain's immune system to active participants that are able to dictate enduring outcomes. Despite these advances, little attention has been paid to one of the most critical components of early brain developmentsexual differentiation. Mounting evidence suggests that the normal developmental functions microglia performcell number regulation and synaptic connectivitymay be involved in the sex-specific patterning of the brain during these early sensitive periods, and may have lasting sex-dependent and sex-independent effects on behavior. In this review, we outline the known functions of microglia during developmental sensitive periods, and highlight the role they play in the establishment of sex differences in brain and behavior. We also propose a framework for how researchers can incorporate microglia in their study of sex differences and vice versa. (c) 2017 Wiley Periodicals, Inc. Develop Neurobiol 78: 580-592, 2018
引用
收藏
页码：580 / 592
页数：13
相关论文
共 104 条
  • [51] Microglia promote the death of developing Purkinje cells
    Marín-Teva, JL
    Dusart, I
    Colin, C
    Gervais, A
    van Rooijen, N
    Mallat, M
    [J]. NEURON, 2004, 41 (04) : 535 - 547
  • [52] Microglia development follows a stepwise program to regulate brain homeostasis
    Matcovitch-Natan, Orit
    Winter, Deborah R.
    Giladi, Amir
    Aguilar, Stephanie Vargas
    Spinrad, Amit
    Sarrazin, Sandrine
    Ben-Yehuda, Hila
    David, Eyal
    Gonzalez, Fabiola Zelada
    Perrin, Pierre
    Keren-Shaul, Hadas
    Gury, Meital
    Lara-Astaiso, David
    Thaiss, Christoph A.
    Cohen, Merav
    Halpern, Keren Bahar
    Baruch, Kuti
    Deczkowska, Aleksandra
    Lorenzo-Vivas, Erika
    Itzkovitz, Shalev
    Elinav, Eran
    Sieweke, Michael H.
    Schwartz, Michal
    Amit, Ido
    [J]. SCIENCE, 2016, 353 (6301)
  • [53] Estradiol and the developing brain
    Mccarthy, Margaret M.
    [J]. PHYSIOLOGICAL REVIEWS, 2008, 88 (01) : 91 - 124
  • [54] Fast, furious and enduring: Sensitive versus critical periods in sexual differentiation of the brain
    McCarthy, Margaret M.
    Herold, Kevin
    Stockman, Sara L.
    [J]. PHYSIOLOGY & BEHAVIOR, 2018, 187 : 13 - 19
  • [55] McCarthy MM, 2017, HORMONES, BRAIN AND BEHAVIOR, VOL 5: DEVELOPMENT OF HORMONE-BEHAVIOR RELATIONSHIPS, 3RD EDITION, P3, DOI 10.1016/B978-0-12-803592-4.00091-2
  • [56] Surprising origins of sex differences in the brain
    McCarthy, Margaret M.
    Pickett, Lindsay A.
    VanRyzin, Jonathan W.
    Kight, Katherine E.
    [J]. HORMONES AND BEHAVIOR, 2015, 76 : 3 - 10
  • [57] Microglia contact induces synapse formation in developing somatosensory cortex
    Miyamoto, Akiko
    Wake, Hiroaki
    Ishikawa, Ayako Wendy
    Eto, Kei
    Shibata, Keisuke
    Murakoshi, Hideji
    Koizumi, Schuichi
    Moorhouse, Andrew J.
    Yoshimura, Yumiko
    Nabekura, Junichi
    [J]. NATURE COMMUNICATIONS, 2016, 7
  • [58] Entry and distribution of microglial cells in human embryonic and fetal cerebral cortex
    Monier, Anne
    Adle-Biassette, Homa
    Delezoide, Anne-Lise
    Evrard, Philippe
    Gressens, Pierre
    Verney, Catherine
    [J]. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2007, 66 (05) : 372 - 382
  • [59] Microglia release activators of neuronal proliferation mediated by activation of mitogen-activated protein kinase, phosphatidylinositol-3-kinase/Akt and delta-Notch signalling cascades
    Morgan, SC
    Taylor, DL
    Pocock, JM
    [J]. JOURNAL OF NEUROCHEMISTRY, 2004, 90 (01) : 89 - 101
  • [60] NEURONAL DEATH IN THE DEVELOPING SEXUALLY DIMORPHIC PERIVENTRICULAR NUCLEUS OF THE PREOPTIC AREA IN THE FEMALE RAT - EFFECT OF NEONATAL ANDROGEN TREATMENT
    MURAKAMI, S
    ARAI, Y
    [J]. NEUROSCIENCE LETTERS, 1989, 102 (2-3) : 185 - 190
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