Microglia: Driving critical periods and sexual differentiation of the brain

被引：59
作者：
VanRyzi, Jonathan W. [1 ,2 ]
Pickett, Lindsay A. [1 ,2 ]
McCarthy, Margaret M. [1 ,2 ]
机构：
[1] Univ Maryland, Dept Pharmacol, Sch Med, Baltimore, MD 21201 USA
[2] Univ Maryland, Sch Med, Program Neurosci, Baltimore, MD 21201 USA
来源：
DEVELOPMENTAL NEUROBIOLOGY | 2018年 / 78卷 / 06期
关键词：
microglia; sexual differentiation; sex differences; critical (sensitive) period; brain development; neuroimmunology; behavior; CENTRAL-NERVOUS-SYSTEM; EARLY-LIFE EXPERIENCE; CEREBRAL-CORTEX; NEURONAL DEATH; PREOPTIC AREA; CELL-DEATH; IN-VIVO; PERIVENTRICULAR NUCLEUS; ANTIINFLAMMATORY IL-10; SOCIAL-BEHAVIOR;
D O I：
10.1002/dneu.22569
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The proverbial role of microglia during brain development is shifting from passive members of the brain's immune system to active participants that are able to dictate enduring outcomes. Despite these advances, little attention has been paid to one of the most critical components of early brain developmentsexual differentiation. Mounting evidence suggests that the normal developmental functions microglia performcell number regulation and synaptic connectivitymay be involved in the sex-specific patterning of the brain during these early sensitive periods, and may have lasting sex-dependent and sex-independent effects on behavior. In this review, we outline the known functions of microglia during developmental sensitive periods, and highlight the role they play in the establishment of sex differences in brain and behavior. We also propose a framework for how researchers can incorporate microglia in their study of sex differences and vice versa. (c) 2017 Wiley Periodicals, Inc. Develop Neurobiol 78: 580-592, 2018
引用
收藏
页码：580 / 592
页数：13
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