Sensitivity Analysis of the Electrocardiogram in Mouse Heart

被引：0
|
作者：
Ramirez-Hurtado, Alberto [1 ]
Castano-Arcila, Mauricio [1 ]
Montesinos Larrinaga, Humberto [1 ]
Rodriguez-Gonzalez, Jesus [1 ]
机构：
[1] Natl Polytech Inst, Unit Monterrey, Ctr Res & Adv Studies, Apodaca 66600, Mexico
来源：
IFAC PAPERSONLINE | 2020年 / 53卷 / 02期
关键词：
Control of physiological variables; bio-signals analysis and interpretation; systems biology; physiological model; modeling and identification; isolated heart; MODEL;
D O I：
10.1016/j.ifacol.2020.12.427
中图分类号：
TP [自动化技术、计算机技术];
学科分类号：
0812 ;
摘要：
The function of the heart is contracting and pump oxygenated blood to the body and deoxygenated blood to the lungs. To achieve this goal heart must beat regularly and continuously for entire life and respond to the changing requirements by the body. In this paper, we consider a mathematical model to produce ECG and analyze how the parametric variation can modify the electrocardiogram signal in the mouse heart. Numerical simulations were analyzed in detail, and compared with the control experiment, changes in frequency and ECG characteristics were evaluated. In agreement with physiological function, we find that the frequency of pacemaker cells can vary significantly, whereas electrical conducting cells maintain ECG characteristics in the face of parametric variations. P-wave, QRS complex, and T-wave can vary significantly in myocardial cells to parametric variations. Copyright (C) 2020 The Authors.
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页码：16087 / 16091
页数：5
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