Guilty as charged: B-RAF is a human oncogene

被引：659

作者：

Garnett, MJ ^{[1
]}

Marais, R ^{[1
]}

机构：

[1] Inst Canc Res, Canc Res UK Ctr Cell & Mol Biol, Signal Transduct Team, London SW3 6JB, England

来源：

CANCER CELL | 2004年 / 6卷 / 04期

关键词：

D O I：

10.1016/j.ccr.2004.09.022

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

RAF proteins are components of a conserved signaling pathway that regulates cellular responses to extracellular signals. Despite over 20 years of research into the regulation and function of the RAF proteins, it was only realized recently that the B-RAF isoform is mutated at a high frequency in human cancer. Here we review the rapid progress made in our understanding of B-RAF as an oncogene and of its role in cancer.

引用

页码：313 / 319

页数：7

共 45 条

[1] Ras activation of the Raf kinase: Tyrosine kinase recruitment of the MAP kinase cascade [J].

Avruch, J ;

Khokhlatchev, A ;

Kyriakis, JM ;

Luo, ZJ ;

Tzivion, G ;

Vavvas, D ;

Zhang, XF .

RECENT PROGRESS IN HORMONE RESEARCH, VOL 56, 2001, 56 :127-155

[2]

BOS JL, 1989, CANCER RES, V49, P4682

[3]

Brose MS, 2002, CANCER RES, V62, P6997

[4] Ras mediates the cAMP-dependent activation of extracellular signal-regulated kinases (ERKs) in melanocytes [J].

Buscà, R ;

Abbe, P ;

Mantoux, F ;

Aberdam, E ;

Peyssonnaux, C ;

Eychène, A ;

Ortonne, JP ;

Ballotti, R .

EMBO JOURNAL, 2000, 19 (12) :2900-2910

[5] Mutations of the BRAF gene in human cancer [J].

Davies, H ;

Bignell, GR ;

Cox, C ;

Stephens, P ;

Edkins, S ;

Clegg, S ;

Teague, J ;

Woffendin, H ;

Garnett, MJ ;

Bottomley, W ;

Davis, N ;

Dicks, N ;

Ewing, R ;

Floyd, Y ;

Gray, K ;

Hall, S ;

Hawes, R ;

Hughes, J ;

Kosmidou, V ;

Menzies, A ;

Mould, C ;

Parker, A ;

Stevens, C ;

Watt, S ;

Hooper, S ;

Wilson, R ;

Jayatilake, H ;

Gusterson, BA ;

Cooper, C ;

Shipley, J ;

Hargrave, D ;

Pritchard-Jones, K ;

Maitland, N ;

Chenevix-Trench, G ;

Riggins, GJ ;

Bigner, DD ;

Palmieri, G ;

Cossu, A ;

Flanagan, A ;

Nicholson, A ;

Ho, JWC ;

Leung, SY ;

Yuen, ST ;

Weber, BL ;

Siegler, HF ;

Darrow, TL ;

Paterson, H ;

Marais, R ;

Marshall, CJ ;

Wooster, R .

NATURE, 2002, 417 (6892) :949-954

[6] THE SPECIFICITY OF P53 MUTATION SPECTRA IN SUNLIGHT-INDUCED HUMAN CANCERS [J].

DAYAGROSJEAN, L ;

DUMAZ, N ;

SARASIN, A .

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 1995, 28 (02) :115-124

[7]

DeVita VT., 2001, CANC PRINCIPLES PRAC

[8] Absence of BRAF mutations in UV-protected mucosal melanomas [J].

Edwards, RH ;

Ward, MR ;

Wu, H ;

Medina, CA ;

Brose, MS ;

Volpe, P ;

Lee, SN ;

Haupt, HM ;

Martin, AM ;

Herlyn, M ;

Lessin, SR ;

Weber, BL .

JOURNAL OF MEDICAL GENETICS, 2004, 41 (04) :270-272

[9] CRITICAL TYROSINE RESIDUES REGULATE THE ENZYMATIC AND BIOLOGICAL-ACTIVITY OF RAF-1 KINASE [J].

FABIAN, JR ;

DAAR, IO ;

MORRISON, DK .

MOLECULAR AND CELLULAR BIOLOGY, 1993, 13 (11) :7170-7179

[10] Mutation analysis of the BRAF, ARAF and RAF-1 genes in human colorectal adenocarcinomas [J].

Fransén, K ;

Klintenäs, M ;

Österström, A ;

Dimberg, J ;

Monstein, HJ ;

Söderkvist, P .

CARCINOGENESIS, 2004, 25 (04) :527-533

← 1 2 3 4 5 →