Emergence of fluconazole-resistant sterol 14-demethylase P450 (CYP51) in Candida albicans is a model demonstrating the diversification mechanism of P450

被引：13
|
作者：
Aoyama, Y
Kudo, M
Asai, K
Okonogi, K
Horiuchi, T
Gotoh, O
Yoshida, Y
机构：
[1] Mukogawa Womens Univ, Sch Pharmaceut Sci, Nishinomiya, Hyogo 6638179, Japan
[2] Soka Univ, Fac Engn, Dept Bioengn, Tokyo 1928577, Japan
[3] Mukogawa Womens Univ, Interdisciplinary Res Inst Biosci, Nishinomiya, Hyogo 6638179, Japan
[4] Takeda Chem Ind Ltd, Div Pharmaceut Res, Osaka 5328686, Japan
[5] Saitama Canc Ctr, Res Inst, Ina, Saitama 3620806, Japan
来源：
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 2000年 / 379卷 / 01期
关键词：
D O I：
10.1006/abbi.2000.1852
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
收藏
页码：170 / 171
页数：2
相关论文
共 50 条
  • [41] An old activity in the cytochrome P450 superfamily (CYP51) and a new story of drugs and resistance
    Kelly, SL
    Lamb, DC
    Cannieux, M
    Greetham, D
    Jackson, CJ
    Marczylo, T
    Ugochukwu, C
    Kelly, DE
    BIOCHEMICAL SOCIETY TRANSACTIONS, 2001, 29 : 122 - 128
  • [42] A functional cytochrome P450 lanosterol 14α-demethylase CYP51 enzyme in the acrosome:: Transport through the Golgi and synthesis of meiosis-activating sterols
    Cotman, M
    Jezek, D
    Tacer, KF
    Frangez, R
    Rozman, D
    ENDOCRINOLOGY, 2004, 145 (03) : 1419 - 1426
  • [43] The Construction and Characterization of Self-sufficient Sterol 14-Demethylase Fusion Proteins consisting of Yeast CYP51 and NADPH-450 reductase
    Kitahama, Y.
    Nakamura, M.
    Yoshida, Y.
    Aoyama, Y.
    16TH INTERNATIONAL CONFERENCE ON CYTOCHROME P450, PROCEEDINGS, 2009, : 41 - +
  • [44] A comparison of the bacterial CYP51 cytochrome P450 enzymes from Mycobacterium marinum and Mycobacterium tuberculosis
    Mohamed, Hebatalla
    Child, Stella A.
    Bruning, John B.
    Bell, Stephen G.
    JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2022, 221
  • [45] Polymorphism and expression level of CYP51 (cytochrome P450) and sensitivity to ipconazole in Fusarium fujikuroi isolates
    Tateishi, Hideaki
    Miyake, Taiji
    Suga, Haruhisa
    JOURNAL OF PESTICIDE SCIENCE, 2019, 44 (1-2) : 25 - 32
  • [46] Evidence for recycling of cytochrome P450 sterol 14-demethylase from the cis-Golgi compartment to the endoplasmic reticulum (ER) upon saturation of the ER-retention mechanism
    Homma, K
    Yoshida, Y
    Nakano, A
    JOURNAL OF BIOCHEMISTRY, 2000, 127 (05): : 747 - 754
  • [47] Cloning and expression in Escherichia coli of the obtusifoliol 14 alpha-demethylase of Sorghum bicolor (L) Moench, a cytochrome P450 orthologous to the sterol 14 alpha-demethylases (CYP51) from fungi and mammals
    Bak, S
    Kahn, RA
    Olsen, CE
    Halkier, BA
    PLANT JOURNAL, 1997, 11 (02): : 191 - 201
  • [48] Recent progress in the CYP51 research focusing on its unique evolutionary and functional characteristics as a diversozyme P450
    Aoyama, Y
    FRONTIERS IN BIOSCIENCE, 2005, 10 : 1546 - 1557
  • [49] Biochemical analysis of a multifunctional cytochrome P450 (CYP51) enzyme required for synthesis of antimicrobial triterpenes in plants
    Geisler, Katrin
    Hughes, Richard K.
    Sainsbury, Frank
    Lomonossoff, George P.
    Rejzek, Martin
    Fairhurst, Shirley
    Olsen, Carl-Erik
    Motawia, Mohammed Saddik
    Melton, Rachel E.
    Hemmings, Andrew M.
    Bak, Soren
    Osbourn, Anne
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (35) : E3360 - E3367
  • [50] Lanosterol 14α-demethylase (CYP51), NADPH-cytochrome P450 reductase and squalene synthase in spermatogenesis:: late spermatids of the rat express proteins needed to synthesize follicular fluid meiosis activating sterol
    Majdic, G
    Parvinen, M
    Bellamine, A
    Harwood, HJ
    Ku, WW
    Waterman, MR
    Rozman, D
    JOURNAL OF ENDOCRINOLOGY, 2000, 166 (02) : 463 - 474
12345