Strategies for discovering drugs from previously unexplored natural products

被引：347
作者：
Harvey, A [1 ]
机构：
[1] Drug Discovery Ltd, Glasgow G1 1XW, Lanark, Scotland
来源：
DRUG DISCOVERY TODAY | 2000年 / 5卷 / 07期
关键词：
D O I：
10.1016/S1359-6446(00)01511-7
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Natural products are the most consistently successful source of drug leads. Despite this, their use in drug discovery has fallen out of favour. Natural products continue to provide greater structural diversity than standard combinatorial chemistry and so they offer major opportunities for finding novel low molecular weight lead structures that are active against a wide range of assay targets. As less than 10% of the world's biodiversity has been tested for biological activity, many more useful natural lead compounds are awaiting discovery. The challenge is how to access this natural chemical diversity.
引用
收藏
页码：294 / 300
页数：7
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